Scientist

Supports the planning and execution of research experiments in the context of the laboratorys overall research program.

• Advance the science in the laboratory through new procedures and discoveries. 1
• Develop product-specific clinical formulations for vaccines and biotherapeutics for Phase 1/II manufacturing under guidance of Federal Task Leaders including: Project design Experimental design Study coordination within the Formulation Development group Timeline planning Evaluation and protection of data integrity 2

Supports laboratory staff on research projects and techniques.

• Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis in the development of novel research treatments.
• Serve as Formulation Development Subject Matter Expert for one formulation development team in the areas of: Formulation theory and experiment design Experiment execution and instrument operation Data analysis and interpretation 3

Maintains laboratory equipment and the training of others in their use.

• Operate troubleshoot and train others to use laboratory equipment and software.

Assists in maintaining adequate space and facilities for ongoing and projected research studies.

• Manage scientific equipment and resources (e.g. reagents stocks of frozen sells animal samples) including acquisition documentation and storage.

Evaluates analyzes and interprets research data communicates results and methods in reports presentations and manuscripts.

• Maintain a detailed and up-to-date electronic laboratory notebook detailing all experiments.
• Analyze collate and interpret data employing in-depth knowledge of protein chemistry protein formulation and method theory independently and in collaboration with team members.

Coordinates with junior staff to modify research protocols.

• Suggest alternative or complementary approaches to experiments.

Presents research at national scientific meetings and symposia.

• Write papers and abstracts detailing research efforts and results for publication in peer-reviewed journals; prepare PowerPoint presentations as appropriate.
• Review edit and as needed write first drafts of papers posters and manuscripts.
• Give posters and presentations detailing work at regional and national scientific meetings.
• Lead communications within the VRC/VPP including: Participation in cross-functional teams Coordination of internal and interdepartmental activities Communication with VRC Project Management regarding timelines Collaboration with other VRC and
• NIAID groups Presentation of data in all the above as needed to support other listed tasks

Provides interpretation of results guidance and scientific support to the management team.

• Search existing literature for new and/or relevant techniques.
• Develop assays for vaccine and biotherapeutic characterization under guidance of Federal Task Leaders including: Experimental Design incorporating knowledge of Phase 1 assay development principles as outlined in ICH guidelines Study Coordination within the Formulation Development group Evaluation and identification of instrumentation and related technologies for successful assay completion to advise Federal Task Leader based on subject matter expertise. Analyze and interpret data Perform bench side sample analyses using both standard and advanced study specific analytical methods as needed to further VRC Formulation Development projects and/or support other project teams. Prepare technical reports and protocols documenting formulation stability and method development studies including drafting reviewing editing and verification of data. Contribute to professional manuscripts based on results of formulation stability and method development studies including drafting reviewing editing and verification of data. Provide general technical guidance and training to Formulation team members. Oversee external service and execute routine maintenance and troubleshooting for one or more pieces of laboratory instrumentation.

Mentors junior level scientists.

• Train staff in a wide variety of techniques used in the laboratory.