Scientist, Bioconjugation

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) Pompe disease and multiple DMD mutations. At Dyne we are on a mission to deliver functional improvement for individuals families and communities. Learn more at and follow us onXLinkedInandFacebook.

Role Summary:

The Scientist Bioconjugation designs synthesizes purifies characterizes andoptimizesnovel bioconjugates that support Dynes therapeutic pipeline. This role appliesexpertisein bioconjugation chemistry protein purification oligonucleotide conjugation and analytical characterization to solve scientific and technical experience in design synthesis purification and/or characterization of antibody-drug conjugates (ADCs) and/or antibody-oligonucleotide conjugates (AOCs) is a Scientist collaborates closely with colleagues across chemistry protein engineering analytical sciences process development biology and other functions to advance therapeutic programs from discovery through development.

Thisposition is basedin Waltham MA

Primary Responsibilities Include:

• Designs and conducts experiments to synthesize and optimize the conjugation of oligonucleotides to proteins peptides and antibodies.
• Develops and evaluates novel conjugation strategies linker technologies and site-specific modification approaches.
• Purifies and characterizes bioconjugates using chromatographic spectroscopic and complementary analytical techniques.
• Analyzes and interprets experimental data to guide molecular design experimental strategy and process optimization.
• Independently troubleshoots complex synthetic purification and analytical challenges.
• Collaborates with cross-functional teams to advance therapeutic candidates and achieve project milestones.
• Maintains detailed and accurate experimental records and communicates findings through technical reports presentations and team discussions.
• Contributes to internal technology development initiatives and bioconjugation platform innovation.
• Supports the transfer of conjugation processes to development and manufacturing teams as programs advance.
• Maintains current knowledge of emerging technologies and scientific literature in bioconjugation protein chemistry and oligonucleotide therapeutics.

Education and Skills Requirements:

• PhD in chemistry biochemistry chemical biology pharmaceutical sciences or a related scientific discipline with 03 years of industry experience; or a masters degree with 8 years of relevant industry experience.
• Hands-on experience in bioconjugation chemistry and protein purification.
• Experience with the conjugation of proteins peptides antibodies or oligonucleotides.
• Strong understanding of linker chemistry conjugation mechanisms and site-specific modification strategies.
• Hands-on experience with purification techniques including HPLC FPLC size-exclusion chromatography ion-exchange chromatography and affinity chromatography.
• Experience with analytical characterization methods such as LC-MS UPLC capillary electrophoresis SDS-PAGE UV-Vis spectroscopy and dynamic light scattering.
• Knowledge of protein chemistry oligonucleotide therapeutics or antibody-based therapeutics.
• Ability to independently design and execute experimental work within defined research projects applying sound scientific methodology to address increasingly complex problems.
• Ability to analyze interpret and clearly communicate experimental data to support program advancement and scientific decision-making.
• Strong scientific curiosity and an innovative solution-oriented mindset.
• Excellent experimental planning execution documentation and organizational skills.
• Effective written and verbal communication skills.
• Strong cross-functional collaboration skills and the ability to work effectively with internal partners toward shared scientific objectives.
• Ability to manage multiple priorities meet timelines and thrive in a fast-paced collaborative biotechnology environment.

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The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education experience job-related knowledge and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job the level of knowledge and skill typically required and the scope of responsibility but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned including work in other functional areas to cover absences or relief to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age color disability gender national origin race religion sexual orientation veteran status or any classification protected by federal state or local law.