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Scientific Associate Director Safety Pharmacology Thousand Oaks CA
Job Location:
Job Location:
Thousand Oaks, CA - USA
Monthly Salary:
$ 235400 - 235400
Monthly Salary:
Posted:
25 May 2026 (30+ days ago)
Posted:
Application Deadline:
22 August 2026
Application Deadline:
Vacancies:
1 Vacancy
Vacancies:
Job Summary
ATTENTION MILITARY AFFILIATED JOB SEEKERS- Our organization works with partner companies to source qualified talent for their open roles. The following position is available toVeterans Transitioning Military National Guard and Reserve Members Military Spouses Wounded Warriors and their Caregivers. If you have the required skill set education requirements and experience please click the submit button and follow the next steps. Unless specifically stated otherwise this role is On-Site at the location detailed in the job post.
What you will do
Lets do this. Lets change the world. The Scientific Associate Director will lead safety pharmacology lab-based activities within the Safety Pharmacology Sciences team and contribute directly to the success of Translational Safety & Risk Sciences (TSRS) the department responsible for nonclinical safety evaluation within Amgen Research. This role reports to the Senior Director of Safety Pharmacology Sciences.
This leadership role has multiple components: management of in vitro cardiac safety and electrophysiology laboratory and staff; lead and coordinate safety issue resolution studies (in vitro; in vivo); serve as a Safety Pharmacology Subject Matter Expert (SME) on project teams; and contribute to external scientific initiatives. The role requires integration of data across multiple assay systems and modalities to support candidate selection risk assessment clinical translation regulatory strategy and advancement of industry best practices.
Key Responsibilities
1. Laboratory Leadership & Talant Management
Oversee the cardiac safety and electrophysiology laboratory a core function responsible for ion channel hiPSC-derived cardiomyocyte and isolated heart assays.
Manage exploratory and GLP-compliant studies including outsourcing protocol development data review and report finalization.
Supervise scientific staff promote their development and ensure high-quality timely data generation study tracking QC reporting and stakeholder communication
Maintain compliance with data integrity safety and environmental standards.
Interface with internal & external partners to establish qualified NAMs models for safety assessment.
2. Safety Pharmacology Subject Matter Expert (SME) on TSRS Teams
Provide expertise to support discovery and development programs and partner with TSRS project team representative (PTR) and other team members (PKDM pathology etc) to ensure aligned and efficient execution of safety strategies
Ensure appropriate evaluation of target- and off target-based safety risks for diverse drug modalities in accordance with evolving ICH guidelines (S7A S7B/E14 etc.).
Guide study design data interpretation and next-step recommendations to support both lead optimization and clinical candidate selection and contribute to regulatory filings or inquiries.
Provide oversight of safety pharmacology strategy across modalities including small molecules biologics and emerging therapeutic approaches
Coordinate investigative studies (e.g. human primary tissue acquisition functional studies etc.) and partner with internal and external (CRO) labs to execute.
Collaborate with relevant experts to evaluate and integrate in vitro and in silico approaches.
3. External Scientific Influence
Build and maintain external collaborations with academic industry and consortium partners to advance mechanistic safety understanding and safety pharmacology best practices
Develop scientific eminence through peer-reviewed publications presentations and invited talks
Promote adoption of human-relevant in vitro models (e.g. stem cellderived cardiomyocytes and other NAMs)
Contribute to industry thinking on emerging modality-specific safety considerations (e.g. oligonucleotides and novel therapeutics)
Lets do this. Lets change the world. The Scientific Associate Director will lead safety pharmacology lab-based activities within the Safety Pharmacology Sciences team and contribute directly to the success of Translational Safety & Risk Sciences (TSRS) the department responsible for nonclinical safety evaluation within Amgen Research. This role reports to the Senior Director of Safety Pharmacology Sciences.
This leadership role has multiple components: management of in vitro cardiac safety and electrophysiology laboratory and staff; lead and coordinate safety issue resolution studies (in vitro; in vivo); serve as a Safety Pharmacology Subject Matter Expert (SME) on project teams; and contribute to external scientific initiatives. The role requires integration of data across multiple assay systems and modalities to support candidate selection risk assessment clinical translation regulatory strategy and advancement of industry best practices.
Key Responsibilities
1. Laboratory Leadership & Talant Management
Oversee the cardiac safety and electrophysiology laboratory a core function responsible for ion channel hiPSC-derived cardiomyocyte and isolated heart assays.
Manage exploratory and GLP-compliant studies including outsourcing protocol development data review and report finalization.
Supervise scientific staff promote their development and ensure high-quality timely data generation study tracking QC reporting and stakeholder communication
Maintain compliance with data integrity safety and environmental standards.
Interface with internal & external partners to establish qualified NAMs models for safety assessment.
2. Safety Pharmacology Subject Matter Expert (SME) on TSRS Teams
Provide expertise to support discovery and development programs and partner with TSRS project team representative (PTR) and other team members (PKDM pathology etc) to ensure aligned and efficient execution of safety strategies
Ensure appropriate evaluation of target- and off target-based safety risks for diverse drug modalities in accordance with evolving ICH guidelines (S7A S7B/E14 etc.).
Guide study design data interpretation and next-step recommendations to support both lead optimization and clinical candidate selection and contribute to regulatory filings or inquiries.
Provide oversight of safety pharmacology strategy across modalities including small molecules biologics and emerging therapeutic approaches
Coordinate investigative studies (e.g. human primary tissue acquisition functional studies etc.) and partner with internal and external (CRO) labs to execute.
Collaborate with relevant experts to evaluate and integrate in vitro and in silico approaches.
3. External Scientific Influence
Build and maintain external collaborations with academic industry and consortium partners to advance mechanistic safety understanding and safety pharmacology best practices
Develop scientific eminence through peer-reviewed publications presentations and invited talks
Promote adoption of human-relevant in vitro models (e.g. stem cellderived cardiomyocytes and other NAMs)
Contribute to industry thinking on emerging modality-specific safety considerations (e.g. oligonucleotides and novel therapeutics)
Additional Qualifications/Responsibilities
We are all different yet we all use our unique contributions to serve patients. The dynamic professional we seek is a leader with these qualifications.
Basic Qualifications:
Doctorate degree and relevant post-doc where applicable and 4 years of relevant scientific experience
OR
Masters degree and 7 years of relevant scientific experience
OR
Bachelors degree and 9 years of relevant scientific experience
Preferred Qualifications:
PhD in Pharmacology Neuroscience Physiology Biomedical Sciences or related field
Broad experience in in vitro and or in vivo safety pharmacology across cardiovascular respiratory and CNS domains
Working knowledge of cardiac ion channel assays (e.g. hERG Nav1.5 Cav1.2) and hiPSC-derived cardiomyocyte and isolated heart assays
Experience managing outsourced studies and CRO relationships
Experience supporting discovery and development project teams as a safety pharmacology SME or toxicology representative.
Familiarity with GLP-enabling safety pharmacology packages and integration with toxicology studies
Demonstrated people leadership and laboratory management experience
Strong cross-functional communication and problem-solving skills
Track record of scientific publications and participation in external scientific forums or consortia
What you can expect of us
As we work to develop treatments that take care of others we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture well support your journey every step of the way.
The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to relevant skills experience and qualifications.
In addition to the base salary Amgen offers a Total Rewards Plan based on eligibility comprising of health and welfare plans for staff and eligible dependents financial plans with opportunities to save towards retirement or other goals work/life balance and career development opportunities that may include:
A comprehensive employee benefits package including a Retirement and Savings Plan with generous company contributions group medical dental and vision coverage life and disability insurance and flexible spending accounts
A discretionary annual bonus program or for field sales representatives a sales-based incentive plan
Stock-based long-term incentives
Award-winning time-off plans
Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.
Salary Range
173991.60USD -235400.40 USD
Required Experience:
Director
About Company
VetJobs & Military Spouse Jobs works with our employer partners to source, screen, and move qualified talent to the desktops of the Hiring Managers. Application is a two-step process, so please be patient with the team. When you submit to a position on our site your information will ... View more
