Research Scientist III, Oligo Chemistry

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At Integrated DNA Technologies (IDT) one ofDanahers15 operating companies our work saves livesand were all united by a shared commitment to innovate for tangible impact.

Youll thrive in a culture of belonging where you and your unique viewpoint matter. And by harnessing Danahers system of continuous improvement you help turn ideas into impact innovating at the speed of life.

Our team at Integrated DNA Technologies (IDT) is united by a commitment to collaboration and scientific excellence building on a strong foundation of innovation expertise and reliability. Guided by our vision to help researchers rapidly move from the lab to life-changing advances we work closely with global partners to accelerate progress and genomics breakthroughs across fields like cancer infectious disease rare genetic disorders and more. At IDT youll be part of a culture rooted in continuous learning and improvementwhere your growth fuels our mission to accelerate the pace of genomics and helps shape a healthier brighter future for all.

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TheResearch Scientist IIIis responsible for developing methods for the production and testing of new oligonucleotide products. The ideal candidate in this laboratory role will work with us to develop new product designs and processes and participate in the transfer of that technology into process/product validation activities. General duties include designing and conducting experiments analyzing and interpreting results followed by communicating those results to both internal and external groups.

This position reports to the Staff Scientist and is part of the Emerging Technology team located in Sunnyvale CA and will be an on-site role.

In this role you will have the opportunity to:

• Develop oligonucleotide synthesis workflows with a strong focus on phosphoramidite chemistry and solidphase synthesis
• Apply organic chemistry principles to improve synthesis efficiency yield and product quality
• Design execute and optimize post-synthesis process steps including cleavage deprotection and purification (e.g. cartridge HPLC or other relevant methods) utilizing highresolution mass spectrometry (LCMS) and complementary analytical techniques to assess oligo identity purity and failure modes
• Contribute to evaluation and implementation of new reagents chemistries or process improvements for oligo synthesis platforms
• Other duties as assigned.

The essential requirements of the job include:

• Masters degree in chemistry organic chemistry biochemistry or a related discipline; Ph.D. preferred.
• 3 years of industrial handson laboratory experience in the synthesis of unique oligonucleotide targets or closely related chemistry
• Strong practical expertise in phosphoramidite chemistry and solidphase oligo synthesis
• Experience using LCMS (highresolution preferred) or other orthogonal methods to characterize oligos and diagnose synthesis or process issues
• Proven experience optimizing synthesis or downstream process steps including cleavage deprotection and purification

Travel Motor Vehicle Record & Physical/Environment Requirements:

• Ability to travel 10% time domestic and international
• Ability to occasionally lift move or carry equipment up to 10lb
• Ability to frequently work in a laboratory environment for extended periods

It would be a plus if you also possess previous experience in:

• Background in high-throughput biology automation and NGS-based analysis.
• Working with prototype instrumentation and collaborating with engineers.
• Environmental health and safety coordination work.

IDT a Danaher operating company offers a broad array of comprehensive competitive benefit programs that add value to our lives. Whether its a health care program or paid time off our programs contribute to life beyond the job. Check out our benefits atDanaher Benefits Info.

The annual salary range OR the hourly range for this role is $110000-$130000.This is the range that we in good faith believe is the range of possible compensation for this role at the time of this posting. This range may be modified in the future. This job is also eligible for bonus/incentive pay.

We offer comprehensive package of benefits including paid time off medical/dental/vision insurance and 401(k) to eligible employees.

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole discretion unless and until paid and may be modified at the Companys sole discretion consistent with the law.

Join our winning team today. Together well accelerate the real-life impact of tomorrows science and technology. We partner with customers across the globe to help them solve their most complex challenges architecting solutions that bring the power of science to life.

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