Principal Software Engineer Variant Knowledge Platform

Labcorp is a leader in diagnostics drug development and healthcare innovation. Across every role we harness data and AI to work smarter move faster and create breakthrough solutions that improve health outcomes for people. With our global scale and deep expertise youll do meaningful work grow your career and make a real impact. Together were improving health and improving lives.

Labcorp is a global leader in diagnostic testing and drug development solutions helping healthcare providers researchers and patients make informed decisions that advance care. Join us in our mission to improve health and improve lives.

Work Schedule

This is a fulltime exempt (salaried) position assigned to a First Shift schedule with standard business hours of Monday through Friday 8:00 a.m. to 5:00 p.m. in your time zone. Business needs may occasionally require flexibility in work hours including earlier later or additional hours with reasonable notice provided when possible.

Responsibilities

• Own the technical design for large ambiguous open-ended problems that span the Variant Knowledge Platform and the broader interpretation stack where there is no clear off-the-shelf solution.
• Define and evolve the data models for variant identity classification and annotation holding a high bar for correctness and consistency. Identity or schema drift in this domain can corrupt classifications platform-wide.
• Design production-grade versioned REST API contracts secured via the platforms identity provider (Okta) that internal consumers and enterprise clients integrate against including versioning deprecation and governance strategies.
• Lead the evolution of the systems that turn raw bioinformatic data into trustworthy variant- and sample-level information and the pipelines that source maintain and serve variant annotations toward real-time multi-tenant operation.
• Drive the architecture for automating evidence placement and classification and for scaling the storage and retrieval of sample- and variant-level data as volume and client count grow.
• Define org-wide system architectures and rally engineers and stakeholders around them through clear rational written design documents and Architecture Decision Records (ADRs).
• Lead cross-team technical programs as a named principal-level lead coordinating design sequencing and delivery across platform boundary/tenancy and curation teams and represent the platform in the Architecture Review Forum.
• Set the strategy for system operability: testing observability (including multi-tenant observability) health monitoring reliability and on-call practices under a you build it you run it model.
• Lead large-scale data migration and backfill efforts such as consolidating legacy interpretation data into VKB with the rigor staging and validation gates such work demands.
• Shape the platforms role in enabling future test content and assay development through its data and services.
• Mentor and level up engineers across multiple teams through technical guidance design review and role-modeling multiplying the orgs overall engineering capability.
• Partner with cross-functional stakeholders across product curation science and clinical to identify business opportunities enabled by the platform and align technical strategy to them.
• Communicate technical vision and trade-offs clearly to audiences ranging from individual engineers to executives securing buy-in for direction-setting decisions.

Minimum Qualifications

• Bachelors Degree.
• Five or more years of experience in REST API and contract design including versioning and depreciation strategy and secure service-to-service authentication (e.g. Okta-based identity).
• Two or more years of experience designing and operating cloud-based services on AWS.
• Five or more years of experience in a primary backend programming language used for data-intensive services (e.g. Python).

Preferred Qualifications

• One or more years of experience in genomics or bioinformatics such as variant interpretation clinical genetics HGVS/variant nomenclature gene/transcript annotation or evidence-based classification.
• Two or more years of experience with event-driven and asynchronous messaging architectures (e.g. AWS SQS) and building clean REST gateways in front of them.
• One or more years of experience working in a regulated or clinical environment including version pinning and validation needs driven by regulatory requirements.

Additional Qualifications

• Experience building multi-tenant platform-as-a-product systems serving multiple internal and external consumers.
• Experience delivering multi-tenant observability and cross-cutting reliability for shared platform services.
• Experience executing large one-time data migrations and backfills with provenance and validation guarantees.
• Experience designing building and operating large-scale distributed backend systems and data platforms in production.
• Experience defining and driving operational excellence across testing strategy observability health monitoring and production reliability.
• Strong data modeling skills for systems where data consistency and correctness are critical including schema evolution and migration at scale.
• Experience of org-wide technical leadership: setting architecture across teams authoring ADRs or equivalent design records and building alignment across engineering and cross-functional partners on ambiguous high-impact initiatives.
• Excellent written and verbal communication including the ability to tailor technical messaging from engineers to executive audiences.
• Familiarity with analytics data ecosystems (e.g. Snowflake) and the trade-offs between batch or lagged and real-time data paths.

Labcorp Genetics is seeking a Principal Software Engineer to help shape and build the Variant Knowledge Platform the team and systems responsible for variant identity classification and annotation. The platform provides the authoritative source of variant truth that powers clinical interpretation curation and analytics across the organization.

In this role you will own ambiguous org-spanning technical problems end to end define the architectures and API contracts that platform consumers build on drive cross-team initiatives and raise the engineering bar for teams well beyond your own. Because variant identity and classification data flow directly into clinical reports and downstream analytics the systems you design must be correct versioned and durable.

Application Window closes 8/7/2026

Pay Range: $180000 - $205000 annually

All job offers will bebased on a candidates skills and prior relevant experience applicabledegrees / certificationsas well as internal equity and market data. The position is also eligible for an annual bonus under the Labcorp Bonus are payable based on corporate and/or business segment performance and are subject to individual performance modifiers.

Benefits: Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical Dental Vision Life STD/LTD 401(k) Paid Time Off (PTO) or Flexible Time Off (FTO) Tuition Reimbursement and Employee Stock Purchase regularly scheduled to work less than 20 hours Casual Intern and Temporary employees are only eligible to participate in the 401(k) who are regularly scheduled toworka 7 on 7 off schedule are eligible to receive all the foregoing benefits except PTO or FTO. For more detailed information pleaseclick here.

Labcorp is proud to be an Equal Opportunity Employer:

Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race religion color national origin sex (including pregnancy childbirth or related medical conditions) family or parental status marital civil union or domestic partnership status sexual orientation gender identity gender expression personal appearance age veteran status disability genetic information or any other legally protected characteristic. Additionally all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law.

We encourage all to apply

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