Principal Scientist Translational Biology & Program Leadership

Job Title: Principal Scientist Translational Biology & Program Leadership

Location: Natick MA

Job Summary:

We are seeking a strategic and scientifically driven Principal Scientist with strong expertise in translational immunology ex vivo biology and therapeutic program leadership to lead cross-functional drug discovery initiatives across oncology autoimmune and inflammatory disease programs.

The successful candidate will play program leadership role in advancing innovative biologics programs from target validation through IND-enabling studies. This individual will integrate translational biology mechanistic pharmacology and clinically relevant human assay platforms to guide candidate selection drive program strategy and enable data-driven decision making.

In addition to technical expertise in ex vivo immune assays and complex 3D model systems the ideal candidate will possess demonstrated experience leading multidisciplinary discovery teams coordinating program activities across functions and influencing strategic direction in a fast-paced biotechnology environment.

This role is highly collaborative and will interface closely with protein engineering in vivo pharmacology translational sciences clinical strategy bioanalytics and CMC teams to ensure successful progression of therapeutic candidates toward development milestones.

Job Responsibilities:

• Provide scientific and strategic leadership for biologics discovery programs across oncology immunology and autoimmune therapeutic areas.
• Lead and coordinate cross-functional teams to advance 12 therapeutic programs from early discovery through candidate selection and IND-enabling studies.
• Drive program strategy timelines milestone planning and data integration to support portfolio decision-making and development progression.
• Design and oversee complex ex vivo immune assays using human PBMCs tumor digests and tissue-derived immune cells to evaluate mechanisms of action efficacy and pharmacodynamic activity.
• Collaborate closely with antibody engineering protein sciences in vivo pharmacology translational medicine and biomarker teams to align scientific strategy and experimental execution.
• Lead mechanism-of-action and translational studies for T cell engagers bispecifics multispecific antibodies ADCs cytokine-based therapeutics and other immunomodulatory modalities.
• Drive scientific innovation by introducing clinically relevant human model systems and emerging technologies to improve translational predictability.
• Present program updates strategic recommendations and key data packages to senior leadership governance committees and external collaborators.
• Mentor junior scientists and contribute to building a high-performing collaborative scientific culture.
• Support preparation of regulatory documentation scientific publications patents and IND-related material

Qualifications:

• PhD in Immunology Cell Biology Pharmacology Cancer Biology or related discipline with 6 years of biotechnology or pharmaceutical industry experience.
• Demonstrated experience leading cross-functional therapeutic programs from discovery through IND-enabling stages.
• Strong background in translational immunology ex vivo human assay systems and mechanistic pharmacology.
• Proven expertise in primary immune cell biology ex vivo immune functional assays and human tissue-based translational models.
• Deep understanding of tumor immunology T cell biology myeloid biology and tumor microenvironment interactions.
• Experience leading biologics modalities including T cell engagers bispecifics multispecifics ADCs cytokine therapeutics or related platforms.
• Strong leadership communication organizational and stakeholder management skills.
• Demonstrated ability to influence scientific strategy and effectively operate within matrixed discovery organizations.
• Experience mentoring scientists and managing collaborative research initiatives.

Preferred Qualifications:

• Prior experience serving as biology lead translational lead or program lead within a drug discovery organization.
• Experience contributing to IND-enabling studies translational biomarker strategies and early clinical planning.
• Proficiency with flow cytometry high-content imaging cytokine profiling platforms and translational data analysis tools.
• Familiarity with FlowJo Incucyte Prism and multiplex immune profiling technologies.
• Track record of scientific publications patents and external presentations in immunology or therapeutic discovery.
• Experience working with external collaborators CROs or strategic partners in support of discovery and development programs

The anticipated pay range for this position is $95000 - $155000

WuXi Biologics is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity national origin or protected veteran status and will not be discriminated against on the basis of disability