Principal Scientist, Structural Biology

Band

Level 4

Job Description Summary

We are seeking a Principal Scientist with deep expertise in Structural Biology to join our team in San Diego CA. This is a highly collaborative and hands-on role spanning end-to-end workflows from protein construct design and protein production through high-resolution structure determination contributing directly to drug discovery programs across multiple therapeutic areas.

Job Description

Internal Job Title: Principal Scientist I/II
Location: onsite San Diego CA #LI-Onsite

About the Role:

At Novartis we are reimagining medicine through scientific excellence and innovation. Within the Discovery Sciences organization the Protein Sciences group plays a pivotal role in advancing early-stage drug discovery by enabling deep structural and functional insights into therapeutic targets. Structural Biology is a cornerstone capability enabling structure-guided drug discovery for some of the most challenging and high-impact targets in medicine.

This is a unique opportunity to join a world-class structural biology team within one of the largest and most innovative pharmaceutical companies. Youll have access to state-of-the-art instrumentation highly skilled and collaborative colleagues and the chance to make meaningful contributions to the discovery and development of life-changing medicines.

Key Responsibilities:

• Lead and execute protein production and X-ray crystallography to elucidate protein-small molecule protein-peptide and/or protein-protein interactions supporting drug discovery initiatives

• Successfully drive gene-to-structural small molecule drug discovery projects

• Leverage knowledge in protein production and structural biology to characterize structure-function relationships investigate novel mechanisms of action and address complex scientific questions

• Collaborate with cross-functional teams including protein scientists biophysicists chemists and computational modelers to facilitate structure-based drug design

• Advance our initiatives and drug discovery programs by leveraging innovative approaches such as applications of AI.

Essential Requirements:

• Ph.D. in structural biology biophysics biochemistry or a related field with over 5 years of relevant experience in X-ray crystallography within either industrial or academic settings

• Demonstrated expertise in protein expression across E. coli insect and mammalian expression systems as well as extensive experience in protein purification and characterization

• Proven track record in application of X-ray crystallography to characterize protein-ligand and protein-protein complexes including crystallization screening and optimization data processing structure refinement and analysis.

• Outstanding communication skills strong ability to collaborate within multidisciplinary teams and ability to work in a fast-paced goal-driven environment.

Desirable Requirements:

• Understanding of AI/ML tools for structural biology

• Experience with biochemical assays and biophysical methods

• Experience with Cryo-EM is a plus

The salary for this position is expected to range between $108500 and $201500 per year for Principal Scientist I and between $119700 and $222300 per year for Principal Scientist II. The final salary offered is determined based on factors like but not limited to relevant skills andexperience and upon joining Novartis will be reviewed periodically. Novartis may change the publishedsalary range based on company and market factors.

Your compensation will include a performance-based cash incentive and depending on the level of therole eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health life anddisability benefits a 401(k) with company contribution and match and a variety of other benefits. Inaddition employees are eligible for a generous time off package including vacation personal daysholidays and other leaves.

To learn more about the culture rewards and benefits we offer our people click here.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment hiring training promotion or other employment practices for reasons of race color religion gender national origin age sexual orientation gender identity or expression marital or veteran status disability or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the application process or in order to perform the essential functions of a position please send an e-mail to call 1 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Range

$108500.00 - $201500.00

Skills Desired

Analytical Skill (Inactive) Analytical Skill (Inactive) Analytical Thinking Chemical Biology Chemistry Clinical Trials Collaboration Communication Skills (Inactive) Curious Mindset Data (Inactive) Data Analysis Design of Experiments (DOE) Detail-Oriented Drug Development Drug Discovery Process Ethics Gene Therapy Immunology Inventory Management Laboratory (Inactive) Leading Project Teams Lifesciences (Inactive) Machine Learning (ML) Management (Inactive) Medical Research 10 more