Principal Scientist, In-vivo CAR-T

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at .

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

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At Johnson & Johnson we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented treated and cured where treatments are smarter and less invasive and solutions are personal.

Through our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for humanity. Learn more at.

As guided by Our Credo Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson we respect the diversity and dignity of our employees and recognize their merit.

We are searching for the best talent for a Principal Scientist In-vivo CAR-T to be based on-site in Malvern PA.

Purpose:

The Principal Scientist will support the development optimization and scale-up of lentiviral vector (LVV) drug product processes from early to late-stage development. The role combines hands-on laboratory work with strong cross-functional collaboration to ensure robust scalable and GMP-ready processes.

Key Responsibilities:

• Lead design and execute LVV process development studies across early and late development stages

• Collaborate with modelling experts and data scientists to identify opportunities where modelling or machine learning can reduce experimental burden improve robustness or define process design space.

• Perform hands-on laboratory work including process design optimization and characterization

• Analyze and interpret data to support process understanding optimization and decision-making

• Support process characterization activities including identification of CPPs and development of robust processes

• Contribute to scale-up and manufacturing readiness including support of technology transfer to internal sites or CMOs

• Collaborate cross-functionally with Analytical Development MSAT Quality Manufacturing and Regulatory teams to ensure alignment on process strategy and execution

• Document experimental work and results in accordance with GxP and data integrity requirements

• Participate in troubleshooting activities and continuous process improvement initiatives

Qualifications:

Required:

• Ph.D. 2-4 years experience B.S. or M.S. with 6-8 years of experience in an appropriate scientific discipline (Life Sciences or Chemical Engineering) is required

• Relevant experience in process development of viral vectors and/or LVV formulation development

• Strong hands-on laboratory experience in drug product or viral vector development

• Understanding of process scale-up technology transfer and GxP principles

• Ability to manage/collaborate in a matrix environment

• Strong scientific problem-solving and data interpretation skills

• Hands-on proactive and detail-oriented approach

• Ability to work effectively in a cross-functional matrixed environment

• Clear and concise communication skills (written and verbal)

• Ability to manage multiple priorities in a dynamic development environment

Preferred:

• Experience with LVV platforms viral vectors and/or advanced therapies

• Familiarity with process validation (e.g. LCPV) and manufacturing support

• Exposure to both early and late-stage development or commercial readiness activities

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation please email the Employee Health Support Center () or contact AskGS to be directed to your accommodation resource.

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