Principal Scientist Emerging Obesity Mechanisms

About the Department

The US-based Emerging Obesity Mechanisms department delivers scientific excellence in energyexpenditure muscle and liverrelated mechanisms of obesity advancing novel smallmolecule and RNAi targets through human in vitro characterization and modeofaction discovery. As part of Obesity Research US it helps diversify the pipeline contributing to the broader Obesity & Cardiometabolic Research goal of building a differentiated pipeline across obesity and its comorbidities.

The Position

Are you a driven and passionate scientist with a strong scientific background in Obesity related comorbidities such as MASH or CVD Do you wish to help shape our research initiatives and contribute to the development of life-changing therapies Look no further! Our company is seeking a highly motivated Principal Scientist to join our Emerging Obesity Mechanisms research team as part of the US Obesity Research Department.

As a Principal Scientist you will be responsible for executing and delivering on our Obesity and Cardiometabolic Comorbidities portfolio and be considered a disease expert. You will be involved in leading and championing target data packages from discovery through IND submissions for our US-based Obesity Research department.

Relationships

Reports to the Director of Emerging Obesity Mechanisms at Novo Nordisk in Massachusetts. Internal relationships include working closely with technical staff & other members of the Obesity Research US leadership team. Additionally regular collaborations with members of other research departments & frequent interaction with project managers project leads governance leadership and other colleagues across global R&D. Individual may indirectly mentor less experienced team members. Individuals may interact with external research collaborators in both academia and industry.

Essential Functions

• Serve as a biology and diseasearea expert for MASH and obesity-related comorbidities focused on peripheral organs (CVD and emerging feel & see indications like osteoarthritis sleep apnea muscle preservation as defined by portfolio strategy).
• Lead target identification validation and maturation of novel obesitycomorbidity targets from idea generation through pre-clinical and clinical-stage gates across smallmolecule and RNAi/siRNA modalities.
• Build and strengthen the mechanismofaction narrative and assemble the scientific rationale data packages and screening plans required for governance review to accelerate progression toward first human dose / IND submission.
• Provide crossfunctional and crosssite scientific leadership coordinating biology activities with pharmacology digital biology/omics and Denmarkbased counterparts and communicating clearly with project teams and stakeholders on strategy unmet need and priorities.
• Cultivate and manage external academic and biotech collaborations to insource targets/assets derisk mechanisms and extend capabilities across MASH and broader obesity comorbidities in line with the sites goal of extracting greater value from external innovation.
• Drive scientific communication through publications participation at conferences and building external interactions with Key Opinion Leaders as assets advance.
• Mentor and upskill junior scientists towards scientific autonomy and leadership capabilities needed to progress and champion targets through the broader Obesity pipeline
• Champion humancentric fitforpurpose drug discovery by prioritizing primary human cells patientrelevant in vitro systems and multiomicsinformed disease modelling to strengthen translational relevance
• Bring deep receptorpharmacology and mechanismofaction expertise to build robust translatable MoA-based datasets across smallmolecule and RNAi modalities.

Qualifications

• Bachelors degree required. Relevant Post-graduate or industry experience required
• 22 years relevant experience required Masters Degree with 16 years relevant industry or post-doctorate experience can be considered. PhD with 10 years relevant industry or post-doctorate experience can be considered
• Relevant required experience includes: small molecules and/or RNAi/siRNA modalities
• Preferred experience includes:Exceptional leadership communication and stakeholder management skills
• Demonstrates excellent verbal and written communication skills

The base compensation range for this position is $180000 to $235000. Base compensation is determined based on a number of factors. This position is also eligible for a company bonus based on individual and company performance. Novo Nordisk offers long-term incentive compensation and or company vehicles depending on the positions level or other company factors.

Employees are also eligible to participate in Company employee benefit programs including medical dental and vision coverage; life insurance; disability insurance; 401(k) savings plan; flexible spending accounts; employee assistance program; tuition reimbursement program; and voluntary benefits such as group legal critical illness identity theft protection pet insurance and auto/home insurance. The Company also offers time off pursuant to its sick time policy flex-able vacation policy and parental leave policy.

We commit to an inclusive recruitment process and equality of opportunity for all our job applicants.

At Novo Nordisk were not chasing quick fixes were creating lasting change for long-term health. For over 100 years weve been driven by a single purpose: to defeat serious chronic diseases and help millions of people live healthier lives. This dedication fuels our constant curiosity and inspires us to push the boundaries of whats possible in healthcare. We embrace diverse perspectives seek out bold ideas and build partnerships rooted in shared purpose. Together were making healthcare more accessible treating and defeating diseases and pioneering solutions that create change spanning generations. When you join us you become part of something bigger a legacy of impact that reaches far beyond today.

Novo Nordisk is an equal opportunity employer. Qualified applicants will receive consideration for employment without regard to race ethnicity color religion sex gender identity sexual orientation national origin disability protected veteran status or any other characteristic protected by local state or federal laws rules or regulations.

If you are interested in applying to Novo Nordisk and need special assistance or an accommodation to apply please call us at 1-. This contact is for accommodation requests only and cannot be used to inquire about the status of applications.