Principal Scientist, Downstream Process Development

Job Description

BPR&D within our Companys Research Laboratories is on a mission to rapidly deliver biotherapeutics to patients by efficiently developing innovative robust manufacturing processes and technologies. To achieve this we work closely with colleagues in Discovery Pre-clinical Early Development Analytical Formulation and Commercial Manufacturing while providing an inclusive environment for all. Beyond process development for pipeline biologics we innovate and build next generation biomanufacturing technologies. Examples include investments for development of continuous manufacturing green and sustainable processes and proprietary technology platforms. We actively publish and engage with the scientific community to influence the field.

As a Principal Scientist you will have the opportunity to influence the future direction of our Companys Downstream Processing of Biologics. You will work with an immensely creative and collaborative team of scientists and engineers to design purification processes while developing technical strategies related to downstream processing for drug candidates in early- and late-stage development.

Responsibilities include but are not limited to:

As an impactful contributor shape and realize innovation across the Biologics pipeline strategy and science

Advance the pipeline by collaborating with cross-functional teams from Research & Manufacturing in a fast-paced multidisciplinary environment

Participate in or lead 1) development of robust and scalable purification processes for biologics in different stages of clinical development 2) process characterization and regulatory filings for successful commercialization

Advance downstream processes by improving efficiency and cost effectiveness through research and innovation while assessing technologies and industry best practices

Collaborate with academia industry and vendors to drive development and early adoption of novel process technologies

Contribute to strategic initiatives; partner with senior leaders to set overall project strategy and guide teams towards its execution

Conceptualize plan and execute projects with effective organizational prioritization and problem-solving skills

Stay abreast of scientific and regulatory landscape; actively present (premier conferences) publish (peer-reviewed journals) and patent

Represent BPR&D as a downstream bioprocess expert in internal cross-functional project teams and external conferences/consortia

Mentor and actively share expertise; guide career development; build strong collaborative teams

Champion compliance and safety; promote a culture of inclusion

MINIMUM EDUCATION REQUIREMENTS:

Ph.D. with 6 years MS with 8 years or BS with 10 years of industry experience and background in Chemical/Biochemical engineering or a related field

REQUIRED EXPERIENCE SKILLS AND COMPETENCIES

Strong fundamental knowledge and subject matter expertise in downstream processing of biologics recent advances and challenges in the field

Expertise in independently conducting and directing the design execution analysis and documentation of all stages of purification process development

Track record of accomplishments in downstream bioprocessing with a history of peer-reviewed publications and presentations

Knowledge of biologics CMC development

Adaptability and agility to prioritize and deliver complex objectives often on tight timelines in a rapidly changing environment

Experience and aptitude to lead work and collaborate in internal and external cross-functional matrixed teams

Action-oriented mindset for creativity; ability to take initiative innovate iterate and problem-solve

Demonstrated commitment to coach and mentor staff to maximize talent development and utilization

Excellent interpersonal and communication skills

PREFERRED EXPERIENCE & SKILLS:

Leadership of CMC development teams

Continuous biomanufacturing integrated with process-analytical technologies

High-throughput experimentation automation and process control

Knowledge of protein expression analytics conjugation chemistry and formulation

Biophysical mechanistic and facility modeling; statistical analysis data-science machine learning artificial intelligence

Required Skills:

Preferred Skills:

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The salary range for this role is

This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employees position within the salary range will be based on several factors including but not limited to relevant education qualifications certifications experience skills geographic location government requirements and business or organizational needs.

The successful candidate will be eligible for annual bonus and long-term incentive if applicable.

We offer a comprehensive package of benefits. Available benefits include medical dental vision healthcare and other insurance benefits (for employee and family) retirement benefits including 401(k) paid holidays vacation and compassionate and sick days. More information about benefits is available at can apply for this role through (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting.

San Francisco Residents Only:We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance

Los Angeles Residents Only:We will consider for employment all qualified applicants including those with criminal histories in a manner consistent with the requirements of applicable state and local laws including the City of Los Angeles Fair Chance Initiative for Hiring Ordinance

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