Principal Research Scientist I, tLNP Process Development

Overview

Targeted lipid nanoparticles (tLNPs) represent a key new modality to enable the effective delivery of mRNA. The tLNP chemistry manufacturing and control (CMC) team (TCT) is a newly formed group under Biologics CMC Development Sciences R&D. The tLNP CMC team focuses on process development for tLNPs including mRNA process development tLNP process development and formulation development.  

The targeted lipid nanoparticle (tLNP) process development team is seeking a highly motivated talented and innovative scientist. This position will play a key role in advancing tLNP programs by serving as a technical expert in targeting moiety conjugation technologies including monoclonal antibodies (mAbs) Fabs and related ligand formats. The successful candidate will partner with mRNA and LNP process development team members to design and implement robust strategies for commercial process development and process addition this individual will work cross-functionally with internal stakeholders and external partners to ensure right-first-time technology transfer of mRNA LNP and conjugation processes into AbbVie GMP manufacturing facilities. 

Key Responsibilities 

• Serve as a technical expert in conjugation technologies for linking targeting moieties such as mAbs Fabs and other ligands to lipid nanoparticles. 
• Independently design execute and interpret critical laboratory experiments to build deep technical understanding of LNP conjugation with emphasis on reaction kinetics process optimization and scalability to commercial manufacturing batch size. 
• Operate with autonomy in laboratory research and method development and proactively initiate scientifically meaningful new areas of investigation that can be incorporated into development programs. 
• Lead or contribute to the development of robust process strategies supporting commercial readiness for targeted LNP programs. 
• Partner with mRNA and LNP process development colleagues as well as PDS&T to drive process characterization and improve process understanding. 
• Provide technical leadership for development execution and interpretation of experiments aimed at optimizing process robustness scalability and manufacturability. 
• Collaborate cross-functionally with key internal and external partners to enable right-first-time tech transfer into AbbVie GMP facilities. 
• Identify technical risks and support mitigation strategies for targeted LNP mRNA and conjugation processes. 
• Contribute to CMC planning technical documentation and cross-functional communication for program advancement. 
• Stay current on emerging technologies platforms and best practices relevant to targeted LNP delivery and conjugation science. 

Qualifications :

• BS or equivalent education and extensive typically 14 years of experience; MS or equivalent education with typically 12 years of experience; PhD with typically 6 years of industry experience in area or scientific area of discipline. 
• Demonstrated ability to operate effectively in a cross-functional matrixed environment. 
• Strong scientific judgment problem-solving skills and attention to detail. 
• Excellent written and verbal communication skills. 
• Experience supporting GMP manufacturing process characterization scale-up or technology transfer is preferred. 
• Strong background in biologics nanoparticle systems conjugation chemistry process development or related CMC disciplines. 
• Previous direct report management responsibilities are preferred. 

Preferred Experience 

• Hands-on experience with conjugation strategies for biologics or targeting ligands. 
• Familiarity with LNP formulation mRNA modalities or advanced drug delivery systems. 
• Experience contributing to commercial process development and/or process characterization. 
• Hands-on experience with tangential flow filtration development in the lab and scale-up. 
• Knowledge of GMP requirements and manufacturing tech transfer expectations. 

Success Factors 

• Establishes deep technical credibility in targeted LNP conjugation and process development. 
• Provides strong scientific and technical leadership across programs and stakeholders. 
• Drives practical scalable solutions that support manufacturability and commercialization. 
• Builds effective partnerships to enable seamless technology transfer into AbbVie GMP facilities. 

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of thisposting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic locationand we may ultimately pay more or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our long-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commissionincentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless anduntil paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

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Work :

No

Employment Type :

Full-time