Principal Research Scientist I, siRNA Synthesis & Analytical Development

The Biotherapeutics and Genetic Medicine (BGM) department at AbbVie is seeking a motivated Principal Research Scientist to join the growing siRNA this role you will work with the genetic medicine teams to establish siRNA synthesis purification and analytical capabilities. You will serve as a subject matter expert in oligonucleotide chemistry and siRNA production with responsibility for generating high-quality siRNA materials to advance genetic medicine studies.

Responsibilities: 

• Lead the siRNA synthesis platform to support various stages of siRNA studies. 
• Oversee solid-phase oligonucleotide synthesis deprotection purification desalting and analytical characterization of siRNA. 
• Troubleshoot synthesis purification and analytical challenges to improve yield purity and scalability. 
• Partner with cross-functional teams including the siRNA screening team the antibody conjugation group and CMC to support platform and project objectives. 
• Ensure rigorous documentation data integrity and compliance with internal quality standards. 
• Track and evaluate emerging technologies and best practices in oligonucleotide and RNA-based therapeutics. 
• Manage and develop a team of 23 scientists to support program goals and deliver high-quality siRNA materials on time.

Qualifications :

• BS MS or PhD in chemistry chemical biology biochemistry or a related field with typically 6 (PhD) 12 (MS) or 14 (BS) years of experience in biotech or pharma.
• Demonstrated expertise in siRNA synthesis purification and characterization.
• Strong knowledge of oligonucleotide chemistry RNA chemistry conjugation chemistry and analytical techniques such as HPLC LC-MS and UV spectroscopy.
• Demonstrated ability to independently address complex technical problems and drive projects forward.
• Excellent communication collaboration and organizational skills.
• Strong track record of presenting complex scientific data to internal and external stakeholders.
• Prior people management experience is a plus.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our short-term and long-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more visit  & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:

Work :

No

Employment Type :

Full-time