Principal Research Scientist I, Analytical R&D for LNP and Small Molecule

For the Principal Research Scientist I position we are seeking a highly motivated experienced analytical scientist to be an Analytical Project Leader in New Chemical Entities (NCEs) drug substance and drug product in both preclinical and clinical programs.  The candidate should have extensive expertise within an R&D environment with a fit for purpose mindset.  Expertise with synthetic molecules in solid oral dosage forms is expected. Additional experience with lipid nanoparticles highly desired. 

The qualified candidate should be able to conceive execute and communicate novel strategies that achieve project goals and department imperatives across a multi-disciplinary research and development organization. They must have experience as an analytical project lead and demonstrate a capability to manage CMC deliverables relevant to early-phase clinical development and on discovery programs with pre-clinical candidate compounds.

The qualified candidate must foster productive collaborations within the global Analytical R&D organization and with R&D cross-functional partners such as Discovery Pre-Clinical Safety Process Chemistry Process Engineering Molecular Profiling and Drug Delivery Drug Product Development and Quality Assurance and CMC-Regulatory.

The qualified candidate will be based at the AbbVie Bioresearch Center in Worcester MA. However they must be able to provide 50% on-site support at the AbbVie Bioresearch Center in Worcester MA and 50% on-site support at the AbbVie Cambridge Crossing site in Cambridge MA according to project needs.

Responsibilities:

• Apply analytical separation and detection modes for complex impurity profiling of pharmaceutical products to advise the selection of molecules with properties suitable for development.
• Generate new scientific proposals and lead those efforts. Anticipate and critically

            evaluate scientific or regulatory advances or competitive threats and respond with

            appropriate new strategies.

• Demonstrate scientific initiative and creativity in research or development activities and maintain a high level of productivity in the lab.
• Embraces the ideas of others nurtures innovation and manages innovation to reality.
• Raises the bar and is never satisfied with the status quo.
• Understand and comply with AbbVie safety quality and regulatory policies and government regulations. 

Qualifications :

• Bachelors Masters or Ph.D. in Analytical Chemistry typically with a minimum of 14 (BS) 12 (MS) or 6 (Ph.D.) years related industry experience.
• Strong technical background in analytical chemistry excellent analytical problem-solving skills. Capable of independently developing and troubleshooting analytical methods.
• Demonstrated leadership with solving technical challenges across therapeutic modalities specifically the lipid nanoparticle (LNP) and small molecule spaces.
• Demonstrated experience with a variety of mass spectrometry (MS) instrumentation and applications for structure elucidation and trace quantitation is highly desired.
• Fundamental understanding and working knowledge of various analytical techniques including HPLC UPLC GC DSC TGA DVS PXRD NMR dissolution.
• Familiarity with the role that physicochemical properties play in drug delivery and formulation design.
• Working knowledge of typical formulation approaches and routes of administration (i.e. IV SC IP PO) across multiple species.
• Knowledge of preclinical and clinical formulation development principles relevant to lipid nanoparticle formulations.
• Demonstrate creative out-of-the-box thinking to solve difficult problems
• Self-motivated hard-working detail-oriented individual able to work in a fast-paced team environment.
• High-quality written and oral communication skills and ability to interact effectively with interdisciplinary scientists and engineers.

Additional Information :

Applicable only to applicants applying to a position in any location with pay disclosure requirements under state or local law: 

• The compensation range described below is the range of possible base pay compensation that the Company believes in good faith it will pay for this role at the time of this posting based on the job grade for this position. Individual compensation paid within this range will depend on many factors including geographic location and we may ultimately pay more or less than the posted range. This range may be modified in the future. 

• We offer a comprehensive package of benefits including paid time off (vacation holidays sick) medical/dental/vision insurance and 401(k) to eligible employees.

• This job is eligible to participate in our long-term incentive programs. 

Note: No amount of pay is considered to be wages or compensation until such amount is earned vested and determinable. The amount and availability of any bonus commission incentive benefits or any other form of compensation and benefits that are allocable to a particular employee remains in the Companys sole and absolute discretion unless and until paid and may be modified at the Companys sole and absolute discretion consistent with applicable law.

AbbVie is an equal opportunity employer and is committed to operating with integrity driving innovation transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. 

US & Puerto Rico only - to learn more visit  & Puerto Rico applicants seeking a reasonable accommodation click here to learn more:

Work :

No

Employment Type :

Full-time