Preclinical Research Project Leader- Internal Medicine

Role Summary:

Leads multiple IM programs and aspects of portfolio/disease area strategy from early discovery through to IND approval

Ability to integrate biology/pharmacology and develop confidence in rationale evidence of mechanism of action in vitro pharmacology data package in vivo studies to enable dose projection and toxicology studies PK/PD biomarker plans and implementation produce all the non-clinical pharmacology contributions to the IB protocols IND and CTAs.

Ensures strategic continuity as programs transition to PTL leadership at the clinical stage. Serves as the key point of contact for scientific strategy on clinical stage project teams.

Accountable formaking appropriate nimble scientific & investment decisions for projects.

Serves as a single point of contact for his/her preclinical assets within the IM category

Leads teams in all relevant governance and senior leadership discussions (e.g. RRC DRC IM LT etc)

Represents the IMRU in interactions with the broader IM Category on asset and disease area strategies

Provides strong cross functional leadership to above asset teams to build and deliver a disease area strategy in areas endorsed by the IM LT.

Ensures smooth transition of projects to clinical development at IND approval.

Responsibilities:

Leads each project in accord with the ethos & urgency of the IM unit (eg invites scientific peer review addresses CIR/CIS as appropriate identifies and mitigates risks ensures the project delivers molecules that survive maximizes competitiveness minimizes cost-to-know maximizes value)

Accountable for definition of a high-quality research strategy and development of preclinical project plans

Provides strong scientific leadership balancing pragmatism and innovation consistent with the research strategy

Delivery of project milestones on schedule and budget. Recommends and enacts the right level of early project investment at risk (particularly DSRD Pharm Sci and clinical) to enable of prioritized projects

Maintains a breadth of therapeutic preclinical research and development expertise that spans cardiometabolic diseases including obesity cardiovascular disease and migraine

Participates in the review of business development opportunities for the IM category and leads due diligence teams to evaluate technical viability of assets for in-licensing.

Serves as the key scientific point of contact for out-licensing programs that have been strategically discontinued.

Represents Pfizer externally as a subject matter expert in various industry/academia/government consortia advisory boards and granting agencies.

Ability to develop and lead KOL panel discussions to inform program and disease area strategies.

Partners with lines to prioritize and resolve resourcing issues in constrained areas

Creates and leads a motivated committed and engaged project team. Models and expects effective team behavior to achieve the project goals

Qualifications:

PhD MD or equivalent with greater than 15 years of expertise in the pharmaceutical industry

Training obtained on-the-job in both the preclinical and clinical environment including matrix team leadership negotiation skills adaptable leadership style clarity in thinking and in communication and building key relationships.

Successfully lead and delivered programs with positive clinical outcomes (ESOE SOCA PSS POC etc) or otherwise increased value of the portfolio

Successfully negotiated with regulatory authorities on study endpoints and/or program acceptability

Scientific excellence; possesses deep knowledge of drug development project area

Ability to operate with a sense of pace and urgency and motivate teams to do the same

Working knowledge of regulatory guidance and environment in US and EU

Excellent communication skills able to present complex technical concepts to enable understanding by colleagues from all disciplines / all levels

Business acumen: possesses excellent knowledge of the business both internal and external with understanding of financial project and disease implications

Thorough understanding of quantitative principles and development of decision criteria across the preclinical and clinical portfolio

Has a drive to increase the value of the IM Category

Acts decisively: timely decision-making

Responds to empowerment by seizing accountability: drives for results

Leads change: deals with ambiguity

Demonstrates business acumen

Candidate demonstrates a breadth of diverse leadership experiences and capabilities including: the ability to influence and collaborate with peers develop and coach others oversee and guide the work of other colleagues to achieve meaningful outcomes and create business impact.
Work Location Assignment:Hybrid

The annual base salary for this position ranges from $214900.00 to $358100.00.* In addition this position is eligible for participation in Pfizers Global Performance Plan with a bonus target of 22.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of lifes moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution paid vacation holiday and personal days paid caregiver/parental and medical leave and health benefits to include medical prescription drug dental and vision coverage. Learn more at Pfizer Candidate Site U.S. Benefits (). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa FL or any location outside of the United States. * The annual base salary for this position in Tampa FL ranges from $193400.00 to $322400.00. This role is posted in multiple locations. If you are applying for the role in an secondary job posting location where pay transparency regulations apply your Talent Advisor will share the local pay information with you during the first interview.

Relocation assistance may be available based on business needs and/or eligibility.

Candidates must be authorized to be employed in the U.S. by any employer.

U.S. work visa sponsorship (such as TN O-1 H-1B etc.) is not available for this role now or in the future.

To learn more about acceptable and prohibited uses of AI during the recruitment process please review our candidate AI-use guidelines available onPfizer Careers.

Continuous Imprv and Proj Mgmt