Postdoctoral Scholar, Translational PKPD

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at .

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About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at are searching for the best talent for a Postdoctoral Scholar Translational PK/PD in Spring House PA.

Purpose: The Translational PK/PD & Investigative Toxicology (TPPIT) team has strong expertise in characterizing ADCs and payloads from both experimental and modeling aspects and the scholar will work as part of a dynamic cross site team within a highly collaborative TPPIT environment partnering with cross functional colleagues across ADC data generation analysis and translational PK/PD modeling. This is a two-year position with the possibility of a third-year extension.

You will be responsible for:

• Advancing translational PK/PD strategies for antibody-drug conjugates (ADCs) by integrating in vitro preclinical and clinical datasets to define exposure-response relationships.
• Building predictive in vitro models using 2D/3D cell culture systems and cell-based assays to characterize ADC and payload activity.
• Using experimental data PK/PD modeling and quantitative analysis to inform ADC candidate selection support human dose projection and reduce reliance on animal studies.

Qualifications / Requirements:

Education: PhD with 0-1 years of experience. Preferred degrees in chemical or biomedical engineering or biopharmaceuticals.

Experience/Skills Required:

• Wet-lab experience in cell culture including 2D and 3D culture systems and cell-based assays such as cytotoxicity assays; familiarity with microscopy and imaging techniques.
• Proficiency in data analysis software such as Prism and ImageJ and MATLAB or familiarity with at least one PK/PD modeling platform such as Monolix or Phoenix.

Preferred Skills:

• Experience with cell and molecular biology assays including the Incucyte live-cell analysis system; familiarity with PK/PD modeling.
• ADC or drug conjugate experience.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource.

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