Postdoctoral Research Fellow
Job Location:
Boston, MA - USA
Monthly Salary:
Posted:
Application Deadline:
Vacancies:
Job Summary
Mass General Brigham relies on a wide range of professionals including doctors nurses business people tech experts researchers and systems analysts to advance our mission. As a not-for-profit we support patient care research teaching and community service striving to provide exceptional care. We believe that high-performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham.
Job Summary
The salary range for this position is $70000 to $ 71750 annually.Please send you CV/Resume Cover Letter and References directly to: Dr. Elisabetta Morini for this position. A linked application is not available.
The Morini Laboratory at the Center for Genomic Medicine at Massachusetts General Hospital (MGH) and Harvard Medical School is seeking a highly motivated Postdoctoral Research Fellow to join our translational research team focused on developing novel therapeutic strategies for Familial Dysautonomia (FD) a rare neurodegenerative disease.
This project aims to evaluate the efficacy of gene editing approaches and small-molecule splicing modulators in a mouse model of FD. The successful candidate will lead in vivo studies and apply molecular cellular and genomic approaches to assess therapeutic outcomes.
We are seeking a creative independent and collaborative scientist with a strong background in molecular neuroscience gene editing RNA biology or neurogenetics. Experience working with mouse models including behavioral assays and molecular analysis of tissues is highly desirable.
This is a unique opportunity to work at the interface of basic science and translational medicine within a collaborative and highly supportive environment. Our lab is part of the MGH/Harvard/Broad Institute ecosystem providing access to state-of-the-art resources and a vibrant scientific community.
Duties and responsibilities:
Design and conduct in vivo efficacy studies to test gene editing strategies and/or compounds in FD mice.
Perform downstream analyses including RNA/protein quantification splicing analysis and histological assessments.
Lead the development and optimization of therapeutic delivery and molecular assays.
Collaborate with internal and external researchers and contribute to mentorship of junior lab members.
Prepare manuscripts present findings at scientific meetings and contribute to grant applications.
The ideal candidate should have received (or expect to receive soon) a Doctoral degree preferred Ph.D. in neuroscience cell or molecular biology human genetics biochemistry or related field.
Qualifications
EDUCATION:
Minimum Required: Doctoral Degree
EXPERIENCE:
Required: Doctoral degree
Preferred: Ph.D. in neuroscience molecular biology genetics or a related field.
Desired skills and competencies:
Molecular biology techniques including DNA RNA and protein isolation and manipulation (RT-PCR qRT-PCR western blotting)
Good understanding of genetic methodologies with experience in cloning CRISPR/Cas genetic editing techniques genomic sequencing
Some level of cell culture experience including cell lines generation transfection/transduction selection propagation preservation and phenotypic characterization
Prior experience with rodent models gene editing or RNA splicing is strongly preferred.
Some experience with microscopy imaging and immuno-cytochemistry (IHC) techniques
Histological and immune-histochemical techniques.
First (or co-first) author of one or more peer-reviewed scientific publications
Excellent English verbal and written communication skills
Able to work both independently and in a team
Interested applicants should submit their CV/Resume Cover Letter and References to: Dr. Elisabetta Morini
Please do not apply through this link.
Additional Job Details (if applicable)
Remote Type
Work Location
EEO Statement:
At Mass General Brigham our competency framework defines what effective leadership looks like by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance make hiring decisions identify development needs mobilize employees across our system and establish a strong talent pipeline.
About Company
Patients at Mass General have access to a vast network of physicians, nearly all of whom are Harvard Medical School faculty and many of whom are leaders within their fields.
