OPS Laboratory Technician

OPS Laboratory Technician

• Bachelors degree in Pharmaceutical Sciences Chemistry Biochemistry Biology Biomedical Sciences Pharmacology or a related field.
• At least one year of laboratory experience in an academic clinical industry or research setting (or equivalent combination of education and experience).
• Experience with sample preparation and bioanalytical assays involving biological specimens.
• Hands-on experience operating and maintaining LC-MS/MS instrumentation.
• Experience analyzing and interpreting LC-MS/MS data.
• Knowledge of pharmacokinetic principles and experience performing basic pharmacokinetic analyses.
• Strong organizational skills attention to detail and ability to work independently and collaboratively within a multidisciplinary research team.

The Laboratory Technician will support research activities within the Center for Pharmacometrics and Systems Pharmacology by performing laboratory and data analysis procedures related to drug quantification pharmacokinetics and molecular biology. The successful candidate will work closely with faculty and trainees to support ongoing translational and clinical pharmacology research projects. Key responsibilities include:

• Perform quantitative bioanalysis of drugs and metabolites in biological matrices (e.g. plasma serum urine tissues) using liquid chromatography-tandem mass spectrometry (LC-MS/MS).
• Prepare biological samples for analysis using extraction techniques including protein precipitation liquid-liquid extraction and solid-phase extraction.
• Develop optimize validate and troubleshoot LC-MS/MS analytical methods following established laboratory procedures.
• Conduct pharmacokinetic (PK) analyses including noncompartmental analyses and preparation of data summaries and reports.
• Perform genotyping analyses including DNA extraction PCR-based assays SNP genotyping and other pharmacogenomic analyses as required.
• Conduct gene expression studies including RNA extraction reverse transcription quantitative PCR (RT-qPCR) and related molecular biology techniques.
• Maintain laboratory equipment instruments and inventories ensuring compliance with laboratory safety and quality standards.
• Document experimental procedures maintain accurate laboratory records and contribute to study reports and manuscripts.

This position is located in Orlando Florida.

$21-$26/hour 40 hours/week

Employment Benefits include:

Health Insurance: UF participates in state-sponsored benefits programs for individuals families and domestic partners and offers voluntary insurance that includes vision dental long-term disability and more. OPS employees are eligible for state benefits if your FTE is 0.75 (30 hours per week) or greater.

Retirement Options: The Federal Insurance Contributions Act (FICA) Alternative Plan is a mandatory retirement savings plan under Internal Revenue Code section 401(a) with Fidelity Investments and is required for eligible OPS employees. You may also voluntarily participate in other retirement saving plans.
To learn more visit: Qualifications:

• Bachelors degree in Pharmaceutical Sciences Chemistry Biochemistry Biology Biomedical Sciences Pharmacology or a related field.
• At least one year of laboratory experience in an academic clinical industry or research setting (or equivalent combination of education and experience).
• Experience with sample preparation and bioanalytical assays involving biological specimens.
• Hands-on experience operating and maintaining LC-MS/MS instrumentation.
• Experience analyzing and interpreting LC-MS/MS data.
• Knowledge of pharmacokinetic principles and experience performing basic pharmacokinetic analyses.
• Strong organizational skills attention to detail and ability to work independently and collaboratively within a multidisciplinary research team

• Masters degree in Pharmaceutical Sciences Pharmacology Biochemistry Molecular Biology or a related discipline.
• Experience with genotyping techniques including DNA extraction PCR qPCR sequencing and SNP analysis.
• Experience with gene expression analysis methods such as RT-qPCR RNA isolation and transcriptomic workflows.
• Experience isolating and characterizing extracellular vesicles and/or exosomes from biological samples.
• Experience with pharmacokinetic/pharmacodynamic (PK/PD) modeling software including Phoenix WinNonlin Monolix NONMEM or similar platforms.
• Experience with bioanalytical method development and validation in accordance with regulatory guidelines.
• Experience contributing to scientific publications grant submissions or presentations.
• Strong written and verbal communication skills.

To be considered you must upload your cover letter resume and list of three professional references.

As a part of our review for research and research support positions we look for a full CV which includes all professional appointments/engagements all post-secondary education and all publications from post-secondary education and all respective dates. Please be sure to not use acronyms in your CV. This CV should include names of entities associated with any projects.

Application must be submitted by 11:55 p.m. (ET) of the posting end date.