Manager, Process Development

Job Description

General Summary:

Vertex is seeking a Manager to lead the Process Development weekend and holiday shift supporting a cell-based therapy for diabetes. This role is accountable for building coaching and coordinating a high-performing team that provides reliable continuity for ongoing cell therapy process development studies. The Manager will translate study plans into clear weekend execution priorities ensure appropriate staffing and training remove operational barriers and maintain strong communication and handoffs across shifts. The Manager will also provide scientific and technical leadership by guiding study design reviewing and interpreting data challenging assumptions and helping the team translate experimental results into sound technical decisions and next steps. Through hands-on coaching and scientific oversight the Manager will foster rigorous data-driven problem solving while developing the technical capabilities of the team.

This is a full-time weekend and holiday shift position based in Vertex facilities in Boston MA. The role requires consistent on-site leadership during assigned shifts and close partnership with weekday Process Development Engineering Facilities EHS and other cross-functional teams.

Key Responsibilities

• Provide direct people management for the weekend shift team of bioprocess associates scientists and engineers including goal setting regular one-on-ones performance feedback development planning recognition and support for career growth.

• Build an inclusive accountable team culture that prioritizes safety quality collaboration respectful communication and reliable delivery.

• Mentor team members in technical execution troubleshooting documentation decision making and effective cross-shift communication; identify skill gaps and coordinate training and qualification plans.

• Own weekend and holiday staffing plans schedules rotations on-call coverage and workload assignments. Balance study needs employee capacity required competencies and facility constraints.

• Partner with weekday study leads to understand objectives critical process steps acceptance criteria risks and escalation paths then convert those inputs into clear and executable weekend coverage plans.

• Lead structured handoffs before and after weekend operations ensuring that priorities deviations observations samples materials equipment status and follow-up actions are clearly documented and communicated.

• Coordinate logistics required for successful execution including room and equipment availability material readiness inventory sample movement documentation access and support from partner functions.

• Manage and/or execute pluripotent stem cell culture and differentiation to support process development optimization and characterization.

• Ensure the team follows approved procedures study instructions established documentation practices safety requirements and applicable GMP expectations.

• Collaborate effectively within departmental teams contribute to deliverables and drive development activities in a cross-functional environment engage on team discussions to resolve issues and lead projects with a fully integrated team to facilitate successful outcomes.

• Partner with technical leads on review of execution records and study outputs. The Manager may contribute technical perspective but is not expected to be the primary owner of experimental design or statistical analysis.

• Coordinate team priorities and resources with departmental leadership contribute to capacity planning and identify opportunities to improve weekend operating models training systems handoffs and team effectiveness.

• Participate in hiring onboarding succession planning and retention activities for the weekend team.

• Communicate team progress capacity risks and support needs to Process Development leadership and cross-functional stakeholders.

• Generate and review technical reports regulatory filings source documents patents and external publications as applicable.

• Demonstrated experience leading teams in a laboratory process development manufacturing or technical operations environment with complex schedules and changing priorities.

• Commitment to maintaining a weekend and holiday shift schedule and providing consistent on-site leadership for the assigned team.

• Strong workforce planning and organizational skills including scheduling delegation prioritization resource coordination and cross-shift handoffs.

• Excellent interpersonal and communication skills with the ability to create clarity build trust resolve conflict and partner effectively in a matrixed organization.

• Working technical knowledge of cell culture or bioprocess operations sufficient to understand study instructions recognize execution risk support troubleshooting and engage technical subject matter experts.

• Experience with controlled documents deviation or investigation support and disciplined documentation practices. Working knowledge of GMP requirements is preferred.

• Ability to lead calmly through operational issues make timely decisions within role authority and escalate appropriately when safety quality study integrity supply or timelines may be affected.

• Pluripotent stem cell culture experience in 2D and/or 3D is preferred but not required.

• Familiarity with cell processing equipment and bioreactor systems such as stirred-tank reactors Unifuge Mini ATF systems and Ambr250 is preferred.

• High attention to detail and the ability to manage multiple concurrent activities while maintaining employee engagement quality and reliable execution.

Requirements

• BS in Biochemistry Engineering Biology or a related discipline with 8 years of relevant industry experience; MS with 5 years; or PhD with 2years. Equivalent combinations of education and experience may be considered.

• Minimum of 2 years of direct people management experience with demonstrated success coaching employees setting expectations providing feedback and supporting development across different experience levels.

At Vertex we embrace continuous learning and encourage employees to stay informed on advances in AI technology automation and industry trends. We seek talent who bring an external perspective demonstrate curiosity and sound judgment and thoughtfully adopt new capabilities that improve decision-making drive innovation increase efficiency and help deliver better outcomes for patients.

Pay Range:

Disclosure Statement:

Flex Designation:

Flex Eligibility Status:

In this On-Site designated role you will work five days per week on-site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertexs Policy on Flex @ Vertex Program and may be changed at any time.

#LI-Onsite

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a persons race color sex gender identity or expression age religion national origin ancestry ethnicity disability veteran status genetic information sexual orientation marital status or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager or contact Talent Acquisition at