Executive Director, Program and Portfolio Management

MacroGenics is a leader in the discovery and development of innovative medicines that utilize our next generation antibody-based technologies.â Our team of 150 dedicated individuals is advancing a pipeline of product candidates to treat patients with cancer. Our products and platforms have attracted multiple partnerships with leading pharmaceutical and biotechnology companies around the globe.

The Company considers its employees to be its most valuable asset and we are committed to providing opportunities for individuals to learn and grow as a means to further their professional development. MacroGenics corporate culture promotes an atmosphere of innovation open communication and teamwork where employees can see firsthand how they contribute to the success of the organization.

Summary of Position

The Executive Director Program and Portfolio Management will serve as a senior leader responsible for driving the strategic planning execution and governance of the companys development position plays a crucial role inorchestrating the cross-functional assessments and decisionsrequiredto advanceproduct candidates from discovery through clinical development regulatory approval and candidate willworkcloselywith leadersacrossresearch clinicalnew product planningCMCfinance and business development.â

The role will provide strategic and operational leadership across cross-functional program teams ensuring that program goals development plans timelines budgets risks and decision points are integrated transparent and aligned with corporate priorities. The Executive Director will playa central rolein strengthening portfolio governance enabling high-quality decision-making and building a high-performing Program and Portfolio Management function that supportstimely disciplined and value-driven execution of development programs.

Responsibilities:

• Lead and/or oversee cross-functional program teams responsible for advancing pipeline assets through discovery IND-enabling activities clinical development regulatory submission approval and commercialization.

• Drive the creation integration and execution of comprehensive development plans including program strategy timelines milestones budgets resource needs risks assumptions and key decision points.

• Partner with functional leaders acrossresearchclinicalregulatory CMCfinancenewproductplanning andbusinessdevelopmentto ensure alignment on programobjectivesand execution priorities.

• Establish andmaintainintegrated program and portfolio timelinesidentifyingcritical path activities interdependencies risks and mitigation strategies.

• Lead portfolio management activities including portfolio planning scenario analysis risk and issue management resource alignment budget coordination and development of go/no-go criteria.

• Support and strengthen governance processes by preparing clear data-driven materials and recommendations for senior leadership portfolio review committees governance bodies and as needed the Board of Directors.

• Ensure transparency accountability and disciplined decision-making across program teams and portfolio governance forums.

• Develop track and communicate program and portfolio goals deliverables milestones risks and progress against approved plans.

• Identifyand resolve cross-functional issues that could affect program scope timelines budget quality or strategic alignment.

• Lead manage mentor and develop Program and Portfolio Management team members fostering a culture of accountability collaboration continuous improvement and operational excellence.

• Drive implementationand champion useof programmanagementbest practices tools dashboards processes and operating models to improve efficiency consistency and portfolio visibility.

• Serve as a strategic thought partner to senior leadership on portfolio prioritization development strategy operational trade-offs resourcing and investment decisions.

• Responsibleformaintainingeffectivealliance governanceparticipation injoint steering committees and external partner interactions asappropriate to support partnered programs or strategic collaborations.

• Promote a collaborative transparent and solutions-oriented team environment that enables effective execution in a dynamic biotech/pharmaceutical setting.

Qualifications

Education & Credentials

• Bachelors degree in life sciences biology pharmaceutical sciences chemistry engineering or a related scientific disciplinerequired.

• Advanceddegreesuch as MS PhD PharmD MD or equivalent scientific degree preferred.

• MBA and/or formal training or certification in project/program management such as PMP is preferred but notrequired.

Experience

• Minimum of12yearsofrelevantexperience in the biotechnology pharmaceutical life sciences or healthcare consulting industry

• 7or more years of people management experience with increasing departmental and management responsibility

• Significant experiencein program management portfolio management product development asset strategy or related drug development leadership roles.

• Demonstrated experience leading cross-functional drug development teams across multiple phases of development preferably including early development clinical development regulatory interactions and late-stage development.

• Proventrack recordof successfully managing complex development programs integrated timelines cross-functional budgets risk plans and executive-level deliverables.

• Experienceoperatingwithin formal portfolio governance structures and presenting program or portfolio recommendations to senior leadership.

• Prior experience managing mentoring and developing program management professionals or cross-functional leaders.

• Experience in oncology immunology biologics antibody-based therapeutics or specialty pharmaceutical development preferred.

• Experience working with external partners alliance governance structures CROs CDMOs consultants or other third-party development partners preferred.

KnowledgeSkillsand Abilities

• Deep understanding of the drug discovery and development process including preclinical development IND-enabling activities clinical development regulatory strategy CMC safety and commercialization considerations.

• Strong knowledge of program and portfolio management principles including integrated development planning critical path management risk management resource planning scenario planning and governance support.

• Strategic mindset with the ability to connect program-level execution to broader portfolio and corporateobjectives.

• Strong financial and business acumen including experience with development budgets resource trade-offs portfolio prioritization and value-based decision-making.

• Executive presence and exceptional communication skills including the ability to synthesize complex scientific operational and business information into clear recommendations.

• Demonstrated ability to influence and align senior leaders cross-functional stakeholders and external partners without relying solely on formal authority.

• Excellent leadership andpeoplemanagement skills witha track recordof building mentoring and developing high-performing teams.

• Strong problem-solving skills and the ability to maketimely data-driven decisions in a fast-paced and ambiguous environment.

• Highly organized and detail-oriented with the ability to manage multiple priorities whilemaintainingfocus on strategic goals and portfolio-level impact.

• Collaborative transparent and credible leadership style with the ability to foster trust across scientific clinical operational and business functions.

• Ability toidentifyprocess improvements and implement scalable tools dashboards and operating models to improve portfolio visibility and execution discipline.

• Strongproficiencywith common business and program management tools includingSmartsheetMicrosoft Office PowerPoint Excel project planning tools portfolio dashboards and collaboration platforms.

Required Experience:

Director