Director, Translational Sciences, Translational Research

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The companys RAS(ON) inhibitors daraxonrasib (RMC-6236) a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291) a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805) a RAS(ON) G12D-selective inhibitor; and RMC-5127 a RAS(ON) G12V-selective inhibitor are currently in clinical development. As a new member of the Revolution Medicines team you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

As Director Translational Sciences you will be a key member of Translational Research reporting to the Vice President of Translational Research focusing on:

• Lead the scientific strategy and execution of the Translational Research Assay Core ensuring delivery of high-quality innovative assays supporting discovery and translational programs.

• Establish and continuously evolve assay platforms that enable biomarker discovery pharmacodynamic assessments mechanism-of-action studies and translational hypothesis testing.

• Drive exploratory translational research aimed at understanding mechanisms of sensitivity intrinsic resistance and acquired resistance across the Revolution Medicines portfolio.

• Develop and execute mechanistic studies using patient-derived samples preclinical models and emerging technologies to generate actionable biological insights.

• Identify novel therapeutic vulnerabilities and rational combination strategies based on clinical and preclinical findings.

• Translate observations from clinical studies into research hypotheses that inform target discovery drug discovery and translational strategies.

• Foster seamless bidirectional translation between clinical observations and discovery research.

• Apply functional genomics single-cell and spatial approaches and complementary molecular and cellular methods to generate decision-enabling data.

• Partner with computational scientists to integrate multi-omic datasets with functional biology and generate mechanistic insights.

• Cross-functional Leadership: Partner across Research Translational Medicine Bioinformatics and Clinical Development to integrate findings into biomarker and development strategies.

Responsibilities

• Scientific Leadership & Execution: Design prioritize and interpret rigorous studies using clinically relevant models and patient-derived materials to address key translational questions.

• Reverse Translation & Resistance Biology: Convert patterns of response non-response and progression into experimental studies that define mechanisms and inform novel therapeutic targets and/or combination strategies.

• Data Integration: Integrate experimental results with clinical biomarker and computational datasets to generate actionable insights.

• Capability Building: Establish and evolve internal workflows evaluate new technologies mentor scientists and manage external research partners as needed.

Required Skills Experience & Education:

• PhD MD or equivalent advanced degree in cancer biology molecular or cellular biology biological engineering translational sciences or a related discipline with 10 years of relevant experience.

• Deep expertise in oncology biology and demonstrated success connecting human disease or clinical observations to experimental models and drug-development hypotheses.

• Strong knowledge of targeted therapy oncogenic signaling and mechanisms of drug response and resistance; experience in RAS-driven cancers is highly desirable.

• Experience with functional genomics and high-dimensional profiling technologies including single-cell spatial or integrated multiomic approaches.

• Proven ability to lead cross-functional research influence strategy and communicate clear decision-oriented recommendations.

Preferred Skills:

• Experience establishing or scaling laboratory-based reverse translation or translational research capabilities in biotechnology or pharmaceutical settings.

• Hands-on experience with patient-derived specimens or models perturbational studies and validation of biomarkers or resistance mechanisms.

• Breadth across tumor-intrinsic and tumor-microenvironment biology and experience integrating experimental and computational data.

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