Director, Portfolio Strategy Inflammation & Immunology

The Director Portfolio Strategy is an individual contributor role within the Inflammation & Immunology (I&I) Early Commercial Business part of the Global Commercial Strategy organization reporting to the I&I Portfolio Strategy & Disease Area Lead (DAL). This roleis responsible fordeveloping and supporting portfolio strategy early commercial assessments and investment decision support across the I&I pipeline. The colleague will bring strong strategic judgment analytical rigor and scientific curiosity to help shape portfolio priorities product concepts and differentiated commercial opportunities across autoimmune and inflammatory diseases.

The broader I&I and Rare Disease portfoliorepresentssignificant strategic value to realizing Pfizers vision to achieve leadership via breakthroughs in prioritized diseases and biological axes with the goal of generating highly differentiated multi-indication mega-blockbusters. Today the portfolio delivers more than $10B globally with 22 ongoing clinical studies underway to significantly expand the product portfolio over the next several years. This role will contribute to that ambition by helping shape I&I portfolio strategy and early commercial decision-making across high-value pipeline and lifecycle opportunities.

The Director will partner closely with R&D Medical AffairsGlobal AccessStrategy&Pricing (GASP)BusinessAnalytics& Insights Competitive Intelligence Business Development and US and International Commercial teams to translate scientific clinical market access and competitive insights into clear portfolio recommendations. This role is focused on early commercial strategy and portfolio decision-making. The Director will help advance disciplined trade-off decisions long-range portfolio thinking and AI-enabled ways of working that support patient impact and enterprise value realization for the I&I portfolio.

Responsibilities:

I&I Portfolio Strategy and Long-Range Planning:

• Support development of long-range commercial and portfolio strategy for the I&I Early Commercial Business spanning early pipeline assets lifecycle opportunities and emerging disease areas.

• Synthesize scientific clinical commercial access competitive and patient insights to inform portfolio priorities and strategic trade-offs.

• Assess opportunities across near- mid- and long-term horizons toidentifyareas of differentiated value creation for Pfizers I&I portfolio.

• Translate portfolio strategy into clear recommendations implications and decision materials for leadership and governance discussions.

• Monitor shifts in the I&I scientific and competitive landscape toidentifyemerging trends risks and potential development opportunities.

Early Commercial Assessment and Product Concept Development:

• Develop and refine early commercial assessments for I&I pipeline assets indications mechanisms and disease-area opportunities.

• Support development of product concepts target product profile input positioning hypotheses market archetypes and commercial opportunity assessments.

• Translate unmet need standard of care competitive dynamics patient/HCP insights and access considerations into differentiated commercial hypotheses.

• Provide commercial input to clinical development evidence generation lifecycle andindicationsequencing discussions in partnership with cross-functional colleagues.

• Helpidentifykey value drivers risks uncertainties and evidence needs that may influence future launch potential and portfolio value.

Business Development and External Innovation Support:

• Support commercial assessments of external innovation and Business Development opportunities relevant to the I&I portfolio.

• Contribute to opportunity assessmentsvaluationinputs market-sizing assumptions competitive scenarios and strategic fit evaluations.

• Partner with Business Development R&D BAI GASP and Competitive Intelligence colleagues to pressure-test assumptions andidentifykey decision points.

• Develop clear executive-ready materials that communicate commercialopportunity strategic rationale risks and portfolio implications.

Cross-Functional Partnership and Governance:

• Partner with the I&I Portfolio Strategy & DAL and cross-functional stakeholders to ensure a strong commercial voice is incorporated into early development and portfolio decisions.

• Support preparation for governance forums portfolio reviews strategy discussions and investment decision meetings.

• Build trusted working relationships across R&D Medical Affairs GASP BAI Competitive Intelligence Business Development and Commercial Regions.

• Influence without direct authority by aligning stakeholders around shared insights strategic choices and implications for the I&I portfolio.

AI-Native Ways of Working:

• Use AI-enabled tools to support scientific and competitive landscape synthesis market insight generation scenario development andstrategyworkstream efficiency.

• Apply AI-augmented approaches to accelerate analysisidentifypatterns across complex data sources and improve quality and consistency of strategic outputs.

• Help embed responsible compliant AI-enabled ways of working into early commercial strategy portfolio assessment and decision-support processes.

• Stay current on emerging tools and practices that can strengthen commercial strategy development and portfolio decision-making.

Here Is What You Need (Minimum Requirements)

• Applicant must have a bachelors degree with at least 8 years of experience; OR a masters degree with at least 7 years of experience; OR a PhD with 5 years of experience

• Experience in pharmaceutical biotechnology life sciences strategy consulting corporate strategy commercial development business development forecasting market research analytics or relatedfield.

• Strong strategic and analytical skills withabilityto synthesize complex scientific clinical market access and competitive information into clear recommendations.

• Experience supporting portfolio strategy early commercial assessment business case development opportunity assessment or cross-functional strategic planning.

• Demonstrated ability to manage multiple priorities and deliver high-quality work in a matrixed environment.

• Strong communication organization problem-solving and stakeholder management skills.

Bonus Points If You Have (Preferred Requirements)

• Experience in Inflammation & Immunology autoimmune disease specialty care or other complex therapeutic areas preferred.

• Experience with early commercial strategy commercial development portfolio management corporate strategy or Business Development assessments.

• Ability to quickly understand scientific and clinical data and translate implications for commercial opportunity differentiation and portfolio value.

• Experience developing market assessments product concepts forecasts business cases investment rationales or strategic options for senior decision-makers.

• Understanding ofmarket access dynamics payer considerations evidence generation and value demonstration.

• Comfort working in an AI-native or AI-augmented environment; experience using AI tools to support strategy synthesis or analysis is a plus.

• Ability to thrive in ambiguity make recommendations with incomplete information and adapt to evolving portfolio priorities.

• Discretion sound judgment and trustworthiness in handling confidential or sensitive organizational matters.