Director, Imaging Biomarkers

Dyne Therapeutics is focused on delivering functional improvement for people living with genetically driven neuromuscular diseases. We are developing therapeutics that target muscle and the central nervous system (CNS) to address the root cause of disease. The company is advancing clinical programs for Duchenne muscular dystrophy (DMD) and myotonic dystrophy type 1 (DM1) as well as a preclinical programs for facioscapulohumeral muscular dystrophy (FSHD) and Pompe disease. At Dyne we are on a mission to deliver functional improvement for individuals families and communities. Learn more at and follow us on X LinkedInand Facebook.

Role Summary:

The Director of Imaging Biomarkers leadsthe development and execution of innovative imaging strategies across Dynes therapeutic programs.Thispivotalrolewillensurethat imaging biomarker strategies are scientifically rigorous clinically relevant and conducive to robust therapeutic development. The person in thisrole focuses on enhancing the understanding of diseasemechanismspatient populationsevaluating therapeutic efficacy and supporting clinicaltrialdesigns through innovative imaging approaches.This role is critical to linking early phase research to clinical developmentprovidingessential insights that drive decision making.The person in this roleleveragestheirexpertisein various imaging modalities to develop novel biomarker applications that assess therapeutic efficacy drive patient-centric trial designs andfacilitateregulatory approval processes.This role combines scientific depth with strategic vision driving the discovery validation and application of advanced imaging modalities to enable precision medicine and accelerate drug development. Theperson in this roleservesas a trusted expert and collaborative leader fostering innovation and ensuring scientific rigor in both preclinical and clinical settings.

This role is based in Waltham MA.

Primary ResponsibilitiesInclude:

• Collaborate with cross-functionalteams including clinical development biostatistics and regulatory affairs toensurethat imaging biomarkers are effectively integrated into clinical trial protocols
• Enable the delivery of high-quality data supporting both internal decision making and external communications with stakeholders including regulatory authorities
• Define and execute the imaging biomarker strategy aligned with clinical and translational objectives
• Serve as the subject matter expert for imaging biomarkers acrosspre-clinicaland clinical programs
• Lead thedevelopment validation and qualification of imaging biomarkers for disease characterization patient stratification and pharmacodynamic assessment
• Partner with Clinical Development Translational Biomarkers Biostatistics Data Management and Regulatory teams to integrate imaging biomarkers into Dyne clinical trials
• Evaluate and implementcutting-edgeimaging technologies (e.g. MRI PET CT ultrasound optical imaging)
• Ensure compliance with regulatory standards for imaging biomarker development and qualification
• Collaborate with external imaging CROs academic institutions and technology vendors to deploy imaging biomarkers into Dyne clinical trials
• Oversee vendor selection and budget management for imaging-related activities
• Manage imaging biomarker operations in clinical studies including protocol development support site training and data quality assurance
• Foster a culture of innovation and scientific rigor

Education and SkillsRequirements:

• Ph.D. M.D. or equivalent in BiomedicalEngineeringMedical Physics Radiology or relatedscientific disciplines
• 10 years of experience in imaging biomarker development within pharma biotech or academic research
• Blend of technical knowledge scientific acumen and strategic vision to foster collaborations with academic institutions industry partners and clinicalexperts
• Deep scientificexpertisein at least one major imaging modality(preferably MRI)and a strong understanding of image acquisition processing and analysis
• Proventrack recordin applying imaging biomarkers in clinical trials and regulatory submissions
• Expertiseinquantitative imaging methodologies image analysis software andimagingdata interpretation
• Strong leadership and project management skills with ability to influence across functions
• Excellent communication and presentation skills

Preferred Experience:

• Familiarity with AI/ML approaches for image analysisto improve efficiency accuracy and uncover complex patterns in imaging data
• Understanding and implementation of digital biomarkers using wearables sensors or other digital health technologies
• Knowledge of disease-specific imaging biomarkers (e.g. neurology cardiologyor neuromuscular)

The pay range reflects the base pay range Dyne reasonably expects to pay for this role at the time of posting. Individual compensation depends on factors such as education experience job-related knowledge and demonstrated skills.

The statements contained herein reflect general details as necessary to describe the principles functions for this job the level of knowledge and skill typically required and the scope of responsibility but should not be considered an all-inclusive listing of work requirements. Individuals may perform other duties as assigned including work in other functional areas to cover absences or relief to equalize peak work periods or otherwise balance workload.

Dyne Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age color disability gender national origin race religion sexual orientation veteran status or any classification protected by federal state or local law.