Director, Head of Product Development

What ifWhat if you could join an organization that creates resources and builds life sciences companies that invent breakthrough technologies to transform health care

In todays healthcare system disease diagnosis often relies on invasive procedures such as biopsies which enable direct interrogation of cellular and tissue health at the suspected source of disease. Due to their invasiveness cost and inconvenience to patients these procedures are often performed only after symptomatic disease hasemerged limiting the ability to intervene earlier in disease progression when therapies may be most effective.

Flagship Labs 103 Inc. is a privately held early-stage company developing advanced molecular technologies designed to detecthighly sensitive cell-resolved biological signals from minimally invasive biospecimens. By combining novel molecular profiling approaches with next-generation assay technologies FL103 aims to enable earlier disease detection longitudinal disease monitoring and improved patient stratification across oncology neurodegenerative disease and other major disease areas.

FL103 was founded by Flagship Pioneering an innovation enterprise dedicated to originating and developing companies that invent breakthrough technologies to transform health care agriculture and sustainability. Since Flagships founding in 2000 the firm has originated and fostered more than 100 scientific ventures including Moderna Therapeutics Generate Biomedicines and Indigo Agriculture.

Position Summary:

FL103 is seeking a highly hands-on scientific and operational leader to serve as Director of Product Development. This individual will play a foundational role in translating FL103s early assay and biological discoveries into robust scalable and clinically meaningful diagnostic assays.

Working closely with the companys platform and discovery teams this leader will drive development and optimization of highly multiplexed molecular assays designed for plasma-based applications. The role will focus on improving assay sensitivity specificity reproducibility and overall analytical performance whileestablishingthe operational and technical foundation for future clinical deployment.

The ideal candidate will bring deepexpertisein translational assay development within molecular diagnostics liquid biopsy or advanced biomarker platforms and will have experience converting complex biological signals into deployable diagnostic workflows. This person should thrive in highly collaborative fast-moving environments and be excited tooperateas a player-coach remainingclose to the science while building and mentoring a growing product development organization.

This is a rare opportunity to join a Flagship-founded company at the earliest stages and help build a transformational diagnostic platform at the intersection of molecular biology ultra-sensitive detection technologies and translational medicine.

Key Responsibilities

Product Development & Assay Optimization

• Lead development and optimization of highly multiplexed molecular assays for plasma-based applications

• Translate early biological and assay signals into robust reproducible and clinically meaningful diagnostic outputs

• Identifyand resolve sources of technical variability assay artifacts and background signal

• Drive improvements in assay sensitivity specificity multiplexing performance and reproducibility

• Develop analytical workflows assay QC frameworks and validation strategies to support future clinical deployment

• Helpestablishscalable assay development pipelines and best practices across product development activities

Translational Development

• Partner closely with platform and discovery teams to prioritize and advance clinically actionable programs

• Support development of assays across multiple disease areas including oncology and neurodegenerative diseases

• Build the technical and operational foundation for future CLIA/LDT deployment and clinical validation activities

• Collaborate cross-functionally with computational clinical automation and external partner teams to advance product readiness

Team Leadership & Culture Building

• Build mentor and manage a high-performing assay and product development team

• Operate as a highly engaged player-coach contributing directly to experimental design troubleshooting and assay strategy

• Foster a culture of scientific rigor operational excellence adaptability and mission-driven execution

• Help introduce structure and prioritization into a fast-moving innovation-driven startup environment

External Collaboration & Strategic Engagement

• Interface with external collaborators CROs diagnostic partners and technology vendors to accelerate assay development

• Collaborate closely with founders Flagship leadership and internal business functions to align technical execution with company strategy

• Contribute technicalexpertiseand product development insight in discussions with current and future partners

Qualifications

• PhD in Molecular Biology Bioengineering Biochemistry Biomedical Engineering or related field

• 10 years of industry experience withsignificant experiencedeveloping andoptimizingmolecular diagnostic or liquid biopsy assays

• Proven experience translating early-stage biological discoveries into robust deployable assay workflows

• Deepexpertisein one or more of the following:

• Highly multiplexed molecular assays

• Proximity-based assay technologies

• qPCR and/or NGS-based assay readouts

• Liquid biopsy and plasma-based diagnostics

• Protein and/or RNA biomarker detection

• Ultra-sensitive molecular detection platforms

• Demonstrated experience improving assay reproducibility sensitivity specificity and analytical robustness in complex biological samples

• Experience developing assays intended for clinical studies translational programs CLIA/LDT environments or diagnostic applications

• Strong understanding of assay validation analytical performance metrics and product development workflows

• Experienceoperatingin highly cross-functional environments spanning biology chemistry automation translational science and computational teams

• Prior experience building and mentoring scientific teams in high-growth biotech or diagnostics organizations

• Entrepreneurial mindset with comfortoperatingin ambiguous fast-moving startup environments

• Strong organizational skills scientific rigor and problem-solving capabilities

• Experience with extracellular vesicle biology or advanced cell-resolved diagnostics is a plus but notrequired

About Flagship

Flagship Pioneering is a biotechnology company that invents and builds platform companies each with the potential for multiple products that transform human health or sustainability. Since its launch in 2000 Flagship has originated and fostered more than 100 scientific ventures resulting in more than$90 billionin aggregate value. Many of thecompaniesFlagship has founded have addressed humanitys most urgent challenges: vaccinating billions of people against COVID-19 curing intractable diseases improving human health preempting illness and feeding the world by improving the resiliency and sustainability of agriculture. Flagship has been recognized twice on FORTUNEs Change the World list an annual ranking of companies that have made a positive social and environmental impact through activities that are part of their core business strategies and has been twice named to Fast Companys annual list of the Worlds Most Innovative Companies. Learn more about Flagship at.

Flagship Pioneering is committed toequal employment opportunityregardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability genderidentityor Veteran status.

At Flagship we recognize there is no perfect candidate. If you have some of the experience listed above but not all please apply anyway. Experience comes in manyformsskills are transferable and passion goes a long way. We are dedicated to building diverse and inclusive teams and look forward to learning more about your unique background.

Recruitment & Staffing Agencies:Flagship Pioneering and its affiliated Flagship Lab companies (collectively FSP) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees isstrictly prohibitedunless contacted directly by Flagship Pioneerings internal Talent Acquisition team. Any resumesubmittedby an agency in the absence of a signed agreement will automatically become the property of FSP and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $179000 - $236500. Compensation for the role will depend on a number of factors including a candidates qualifications skills competencies and experience. FL103 currently offers healthcare coverage annual incentive program retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL103s good faith estimate as of the date of publication and may be modified in the future.

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