Director, Global Manufacturing Execution System Lead

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Job Description

The Director Global MES Business Lead is a senior business-facing leadership role accountable for defining governing and scaling the Manufacturing Execution System (MES) strategy across the global manufacturing network. This role serves as the primary bridge between Global Manufacturing Quality Technical Development MSAT/Process Engineering/Automation and IT to ensure MES platforms and business processes enable compliant efficient and digitally enabled operations across all sites.

At the Director level this role owns the global MES product and business process vision and roadmap and is accountable for translating enterprise manufacturing and quality strategies into executable scalable MES capabilities. The role emphasizes strong business ownership cross-functional leadership and operational value delivery while partnering closely with IT and site teams for technical execution.

• Define and maintain the global MES strategy roadmap and operating model aligned with enterprise manufacturing quality and digital transformation objectives.
• Serve as the global business owner for MES and electronic batch records accountable for platform direction lifecycle management and business value realization across sites.
• Establish and govern global MES standards design principles templates and best practices for MES/EBR implementation and sustainment.
• In partnership with Quality develop and maintain standards and best practices for Electronic Batch Record review including approaches and expectations for Review by Exception.
• Own prioritization of MES capabilities enhancements and site demands balancing compliance operational value risk and scalability.

• Act as the primary MES business partner to Global Manufacturing IT Site Operations/Automation Quality Technical Development and Supply Chain organizations.
• Translate manufacturing and quality needs into clear MES requirements capabilities and delivery roadmaps.
• Chair or contribute to cross-functional MES governance forums (e.g. Manufacturing Digital Council MDC) to drive alignment standard adoption and timely decision-making.
• Represent MES in manufacturing digital and quality leadership forums as a trusted subject matter and business advisor.

• Provide business oversight for global MES delivery models including build deployment validation and sustainment in regulated (GxP) environments.
• Ensure consistent compliant approaches to MES change management risk assessment issue resolution deviations and CAPA execution.
• Partner with IT/OT leadership to define and sustain effective run-and-build support models vendor strategies and service ownership.
• Guide MES deployment strategies for new facilities expansions tech transfers and major process changes.

• Ensure MES solutions meet global GMP data integrity validation and regulatory expectations.
• Support health authority inspections internal audits and regulatory engagements related to MES and electronic batch records.
• Embed compliance-by-design and data integrity principles into MES standards processes and operating models.

• Enable digital manufacturing capabilities through MES including integration with automation systems historians ERP and analytics platforms.
• Drive standardization and harmonization of manufacturing workflows while supporting site-specific operational needs.
• Leverage MES data to support operational excellence initiatives such as right-first-time execution cycle time reduction and data-driven decision making.

• Lead and influence global matrixed teams across Manufacturing Quality Engineering and IT without direct line authority.
• Build strong partnerships with site leaders IT delivery teams and external technology partners.
• Drive organizational change management to support MES adoption standardization and maturity across the network.

• Bachelors degree in Engineering Life Sciences or a related technical discipline.
• 12 years of experience in pharmaceutical or biotech manufacturing environments with significant experience in MES/EBR systems.
• Proven experience leading multi-site or global MES initiatives in regulated (GxP) environments.
• Strong understanding of Global Manufacturing process engineering fundamentals and GMP requirements.

• Experience with leading MES platforms (e.g. Werum PAS-X or equivalent) and integration to automation historians and ERP systems.
• Experience supporting inspections audits deviations and change control related to MES.
• Experience across one or more modalities (e.g. biologics cell therapy API OSD).
• Demonstrated success influencing cross-functional matrixed global teams.

• Strong business and operational acumen with the ability to connect MES capabilities to manufacturing and quality outcomes.
• Excellent stakeholder influence and communication skills including engagement with site and functional leaders.
• Ability to translate complex technical concepts into clear actionable business language.
• Structured problem-solving prioritization and decision-making in complex regulated environments.
• Comfort operating at the intersection of Manufacturing Quality and IT/OT.

• A clear pragmatic global MES strategy that is adopted by sites and functions.
• Improved consistency compliance and speed-to-value across MES implementations.
• Strong partnership and credibility with Manufacturing Quality and IT stakeholders globally.
• MES positioned as a foundational enabler for digital manufacturing and data-driven operations.

The salary range for this position is: $210375.00 - $272250.00. Gilead considers a variety of factors when determining base compensation including experience qualifications and geographic location. These considerations mean actual compensation will vary. This position may also be eligible for a discretionary annual bonus discretionary stock-based long-term incentives (eligibility may vary based on role) paid time off and a benefits package. Benefits include company-sponsored medical dental vision and life insurance plans*.

For additional benefits information visit:

Eligible employees may participate in benefit plans subject to the terms and conditions of the applicable plans.

Gilead Sciences Inc. is committed to providing equal employment opportunities to all employees and applicants for employment and is dedicated to fostering an inclusive work environment comprised of diverse perspectives backgrounds and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race color religion national origin sex age sexual orientation physical or mental disabilitygenetic information or characteristic gender identity and expression veteran status or other non-job related characteristics or other prohibited grounds specified in applicable federal state and local order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973 the Vietnam Era Veterans Readjustment Act of 1974 and Title I of the Americans with Disabilities Act of 1990 applicants who require accommodation in the job application process may contact for assistance.

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