Director, CVRM Genomics Therapeutic Area Lead

Make a meaningful impact on patients lives around the world

AstraZenecas mission is to push the boundaries of science to deliver life-changing medicines. The Centre for Genomics Research (CGR) is advancing one of the worlds most ambitious efforts to apply human genomics and population-scale health data to reshape how diseases are understood and how therapeutic decisions are made. Our work enables clinically meaningful genetically informed decision-making across the full drug development pipeline.

A unique leadership opportunity to bridge science and clinical care.

We are seeking a leader with an MD and/or PhD in a relevant biomedical field who sees population genomics as a tool for understanding disease biology guiding therapeutic development and improving patient outcomes.

In this role you will shape how human genetic and multi-omic evidence informs AstraZenecas strategy and pipeline in Cardiovascular Renal and Metabolic (CVRM) diseases. You will play a central role in determining how we select targets design trials stratify patients understand drug response variation and ultimately bring therapies to the patients who will benefit most.

You will also contribute directly to AstraZenecas global scientific footprint working across a 60 partner international network including leading academic medical centers biobanks and industry consortia.

You will report directly to the Vice President Head of the Centre for Genomics Research and serve as a member of the CGR Leadership Team.

As the CVRM Genomics Therapeutic Area Lead you will:

• Support the CVRM Genomic strategy for CGR ensuring strong alignment to unmet patient needs and AstraZenecas therapeutic area priorities.

• Bring clinical reasoning and genetic insight together to identify disease mechanisms prioritize therapeutic targets and develop biomarker and patient identification strategies.

• Integrate genomic multi-omic clinical biomarker and real-world evidence data to evaluate disease heterogeneity and causal mechanistic pathways support mechanism-based development and indication expansion and inform lifecycle management and post-market investigation.

• Collaborate with CVRM TA leadership to apply population genomic insight to inform patient selection and disease subtyping identify clinical biomarkers and biomarker-driven stratification approaches that enhance clinical trial interpretability and raise the likelihood of therapeutic success.

• Contribute to scientific collaboration across AstraZeneca and the global research community leveraging clinical insight to prioritize high-value partnerships and investments.

• Inspire cross-functional teams of scientists clinicians geneticists and data scientists toward shared goals.

Essential Criteria

• MD (or international equivalent) and/or relevant PhD with deep understanding of CVRM disease biology gained through clinical practice translational research or therapeutic development.

• 5 years experience in clinical research and/or drug development in pharmaceutical or academic environments

• Demonstrated ability to apply human genetics or multi-omics to inform disease mechanisms patient stratification therapeutic hypotheses or clinical trial strategy.

• Experience in genetic epidemiology and/or rare variant interpretation including evaluating variant pathogenicity penetrance and clinical relevance in patient populations.

• Proven track record working in complex cross-functional scientific or clinical research across matrixed teams and external partners (e.g. academic biotech consortia).

• Collaborative patient-centered who thrives working across disciplines to solve translational challenges and shape how medicine is developed and used at scale

• Experience contributing to clinical trial design patient enrichment strategies or biomarker-driven study planning.

• Excellent communicator able to convey clinical reasoning and genomic insights to audiences ranging from data scientists to therapy area leadership and governance boards.

• Ability to influence portfolio and investment decisions through scientific and clinical reasoning.

• Experience mentoring and developing scientific talent

Desirable Criteria

• Recognized scientific contributions (publications conference presentations guideline contributions etc.).

• Experience leveraging human genomics to inform clinical development biomarker strategy or real-world evidence studies.

• Familiarity with regulatory ethical or privacy considerations for genomic research.

• Clinical experience

The annual base pay for this position ranges from $181570 to $272356. Our positions offer eligibility for various incentivesan opportunity to receive short-term incentive bonuses equity-based awards for salaried roles and commissions for sales roles. Benefits offered include qualified retirement programs paid time off (i.e. vacation holiday and leaves) as well as health dental and vision coverage in accordance with the terms of the applicable plans.

Office Working Requirements

When we put unexpected teams in the same room we unleash bold thinking with the power to inspire life-changing -person working gives us the platform we need to connect work atpaceand challenge we work on average a minimum ofthree days per weekfrom the office. But thatdoesntmeanwerenot flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world.

At AstraZeneca were dedicated to being a Great Place to Work where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. Theres no better place to make a difference in medicine patients and society. An inclusive culture that champions diversity and collaboration we are committed to lifelong learning growth and development.

Date Posted

Closing Date

Our mission is to build an inclusive environment where equal employment opportunities are available to all applicants and furtherance of that mission we welcome and consider applications from all qualified candidates regardless of their protected characteristics. If you have a disability or special need that requires accommodation please complete the corresponding section in the application form.