Cryo-FIBSEM Staff Scientist, CryoEM Facility

Posting Description

CRYO-FIB/SEM Staff Scientist CryoEM Facility Biology to lead the adoption of next-generation plasma FIB milling and in situ structural biology as the primary expert for the newly installed HydraBio plasma FIB/SEM; advance cellular and tissue imaging by developing cryo-FIB/ET and volume EM workflows including fluorescence-guided targeting precision milling and lift-out; provide user training experimental design consultation and troubleshooting; collaborate on sample preparation tomography and data reconstruction; and drive innovative method development and publications; oversee instrument calibration vendor servicing and facility infrastructure including liquid nitrogen and data storage; represent the facility through tours workshops and scientific outreach strengthening cryo-ET and volume EM research across the Cambridge/Boston community.

The full job description is available here:

Job Requirements

REQUIRED: Masters or Ph.D. in biochemistry structural biology biophysics or a closely related discipline; demonstrated hands-on expertise in cryo-FIB milling technology and scanning electron microscopy (SEM); strong foundation in cryogenic sample preparation methods for cells or tissues; exceptional troubleshooting organizational and interpersonal skills; and strong commitment to collaborative problem-solving and mentoring a diverse scientific community. Single Particle Analysis (SPA) experience is not required for this role.PREFERRED: A minimum of four years of hands-on research experience in biological electron microscopy; experience with transmission electron microscopy (TEM) particularly with cryo-ET data collection setup on a Titan Krios; background in volume EM sample lift-out techniques or cryo-ET data processing workflows including sub-tomogram averaging (STA); experience diagnosing and resolving FIB/SEM hardware or performance issues; or experience supporting users in a shared research facility.

Must have independent authorization to work in the US. Visa sponsorship is not available.

Revised 6/29/2026