Computational Medicinal Chemist

Job Description Summary

Job Description

Internal Job Title: Senior Expert I/II Data Science

Position Location: San Diego CA hybrid

Your Responsibilities Include:

• Drive the design of medicinal chemistry efforts by applying in-depth knowledge of structure-activity relationships (SAR) structure-based and ligand-based drug design a profound understanding of target biology and predictive methods for assessing on- and off-target activity physical properties pharmacokinetics/pharmacodynamics (PK/PD) and synthetic feasibility.

• Thrive at the intersection of experimental and groundbreaking digital technologies with a particular emphasis on expertise in machine learning active learning and physics-based CADD methodologies as applied to small molecule drug discovery as well as in the induced proximity space.

• Stay abreast of scientific literature and engage with internal and external scientists to incorporate biological insights into lead characterization and screening initiatives.

• Collaborate with interdisciplinary project teams to facilitate effective decision-making throughout the target identification lead optimization and drug candidate nomination process. This involves applying and developing predictive models based on high-content and time-resolved screening data including imaging techniques.

• Drive hypothesis generation to enhance clinical success rates for programs involving small molecules peptides RNAs protein degradation molecular glues transient covalent inhibitors and kinetic stabilization of drug-target complexes.

• Take a leading role in cross-disciplinary mechanistic studies using physics-based modeling and simulation biophysical characterization and cellular validation. These studies will inform the strategic targeting strategies of discovery projects aiming for optimal mechanisms of action (MoAs).

Essential Requirements:

• PhD in medicinal chemistry computational chemistry computational biology computational chemical biology or a related field. Candidates with a laboratory-based background in chemistry and biology supplemented with strong computational experience are also encouraged to apply. We will also consider MS applicants with 6 years of relevant Pharma/biotech experience.

• 3 years of experience working with project teams in a drug discovery environment.

• Proven track record of innovation through analogue design leading to significant impact on discovery projects.

• Familiarity with computational drug design tools (e.g. Schrdoinger CCG OpenEye etc.) high-performance computing environments and strong publication history in peer-reviewed journals.

• Proactively anticipates project needs with a clinical focus.

• Demonstrates rigor and diligence in idea substantiation analogue design and experimentation.

• Strong team orientation with multitasking and adaptability in support and leadership roles.

• Effective listener with excellent written and oral communication skills.

• Proficient in data visualization to effectively communicate insights.

Compensation & Benefits:

The salary for this position is expected to range between $126000 and $234000 USD annually for Senior Expert I Data Science and $138600 and $257400 USD annually for Senior Expert II Data Science. The final salary offered is determined based on factors like but not limited to relevant skills andexperience and upon joining Novartis will be reviewed periodically. Novartis may change the publishedsalary range based on company and market factors.

Your compensation will include a performance-based cash incentive and depending on the level of therole eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health life anddisability benefits a 401(k) with company contribution and match and a variety of other benefits. Inaddition employees are eligible for a generous time off package including vacation personal daysholidays and other leaves.

To learn more about the culture rewards and benefits we offer our people click here.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment hiring training promotion or other employment practices for reasons of race color religion sex national origin age sexual orientation gender identity or expression marital or veteran status disability or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the application process or to perform the essential functions of a position please send an e-mail to or call 1 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

Skills Desired