Bioinformatics Intern Protein Design

At Syngenta our goal is to build the most collaborative and trustworthy team in agriculture providing top-quality seeds and innovative crop protection solutions that improve farmers success. We invite you to help shape the future of agriculture and play a role in safely feeding the world while caring for our planet.

Syngentas Bioinformatics Team is seeking a Protein Design Intern in Durham NC. This internship role will be part of a high-performance scientific team developing cutting-edge skills in computational protein design to deliver innovative solutions for agricultural biotechnology.

As part of Syngentas Emerging Talent Program you will gain hands-on experience exposure to day-to-day business operations and opportunities to apply your academic knowledge to real-world challenges while developing your professional skills.

Duration: May 2027 - August 2027

Role Purpose:

• Apply computational protein design methods to generate novel protein candidates and minibinders to selected targets.
• Optimize workflows that integrate protein design structure prediction and ranking approaches to identify promising candidates.
• Evaluate designed protein variants using sequence- and structure-based analyses.

Accountabilities:

• Leverage open-source protein design and structure prediction workflows using tools such as ProteinMPNN BoltzGen and Boltz-2.
• Design rank and filter protein candidates based on predicted structure interface quality and computational metrics.
• Perform structural analysis and annotation of designed proteins and protein-protein interfaces.
• Test and run computational protein design tools in Linux HPC or cloud-based environments such as AWS.
• Develop Python/Bash scripts for data processing workflow automation and visualization.
• Document workflows create user guides and READMEs and present findings to cross-functional teams.
• Collaborate with and take guidance from other scientists to refine design strategy based on biological insights.
• Summarize design results in clear reports visualizations and recommendations for follow-up testing.

Qualifications :

Required Qualifications:

Education:

• Current MS or PhD student in Bioinformatics Computational Biology Structural Biology Biochemistry Computer Science or related field.

Technical:

• Proficiency in Python and basic Bash scripting.
• Basic understanding of protein structure concepts including protein domains structural alignment and protein-protein interfaces.
• Familiarity with protein structure prediction methods such as Boltz-2 or AlphaFold.
• Familiarity with generative protein design or sequence design tools such as RFdiffusion or ProteinMPNN.
• Familiarity with protein structure visualization tools (PyMOL).
• Experience with Linux/Unix command-line environments.

Analytical:

• Ability to work with large datasets and implement reproducible computational workflows.
• Strong problem-solving skills and attention to detail.
• Effective written and verbal communication skills.

Desired Qualifications:

• Experience evaluating protein-protein interfaces using structural or energetic metrics (e.g. PyRosetta).
• Knowledge of protein databases such as PDB UniProt AlphaFoldDB or ESM Metagenomic Atlas.
• Experience with HPC or cloud computing environments such as AWS.
• Experience with workflow automation containerized tools or reproducible software environments.
• Self-motivated with ability to work independently and collaboratively.
• Enthusiasm for learning new computational methods and tools.
• Experience presenting technical work to diverse audiences.

Additional Information :

Salary for this position ranges between $20 - $45 hourly.

What We Offer: 

• A culture that celebrates belonging and collaboration promotes professional development and strives for a work-life balance that supports the team members. 
• Competitive wages
• Ongoing career development resources
• The opportunity to work on meaningful innovative projects that solve problems

Syngenta is committed to creating a culture that celebrates belonging and collaboration promotes professional development and strives for a work-life balance that supports the team members 

Syngenta has been ranked as a top employer by Science Journal. Learn more about our team and our mission here:  is an Equal Opportunity Employer and does not discriminate in recruitment hiring training promotion or any other employment practices for reasons of race color religion gender national origin age sexual orientation marital or veteran status disability or any other legally protected status. 

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Remote Work :

No

Employment Type :

Intern