Automation Cell Culture Biologist

Job Family:

Travel Required:

Clearance Required:

What You Will Do:

We are looking for an Automation Cell Culture Biologist to support research at the National Institute on Aging (NIA) Center for Alzheimers and Related Dementias (CARD). This position supports efforts to characterize genetic pathways associated with Alzheimers disease and related dementias (ADRD) through large-scale automated cell culture experiments using induced pluripotent stem cell (iPSC) models and advanced liquid handling robotics. This is a full-time position located in Bethesda MD.

• Characterize ADRD genetic pathways using human cell-based models and assess mutation effects on molecular readouts in cell culture systems.
• Perform large-scale iPSC cell culture experiments on automated liquid handling platforms and high-throughput robotic systems.
• Program operate calibrate maintain and troubleshoot automated platforms including Hamilton and Tecan systems and laboratory instruments.
• Differentiate phenotype and evaluate the stability of engineered and non-engineered iPSC and iPSC-derived cell lines.
• Design develop and perform laboratory methods procedures automated differentiation protocols and disease-relevant cell type generation for neurons astrocytes and microglia.
• Develop image analysis routines and apply published protocols for cell differentiation microscopy molecular analyses and phenotypic evaluation.
• Plan administer and support biological research activities additional research projects and laboratory initiatives for ADRD programs.
• Collect analyze interpret organize and present scientific data findings recommendations and research updates to team members and stakeholders.
• Maintain accurate digital and physical experimental records laboratory notebooks databases research documentation reagents frozen cell stocks biological samples and storage systems.
• Perform standard immunological techniques including western blotting and immunostaining.
• Train laboratory staff on scientific instrumentation equipment software and proper use of automated systems.
• Support experimental design data acquisition data analysis figure preparation manuscript preparation scientific reports presentations and other research deliverables.

What You Will Need:

• Masters degree in Cell Biology Molecular Biology Genetics Biochemistry Bioengineering Chemical Engineering Neuroscience or a closely related scientific discipline.
• Minimum of TWO (2) years of related experience in a laboratory or research environment.
• GLP experience and hands-on cell culture experience including induced pluripotent stem cell (iPSC) culture.
• Proficiency operating and programming automated liquid handling platforms and robotics preferably Hamilton Tecan Beckman or Agilent systems with experience in experimental planning optimization and quality control testing.
• Skilled in analyzing and interpreting biological or scientific data and maintaining laboratory records notebooks and databases.
• Strong knowledge of laboratory procedures equipment maintenance and proper laboratory disposal methods.
• Proficiency with Microsoft Outlook Excel and PowerPoint.
• Familiarity with R Seurat Google Drive or similar research software platforms; and programming or coding knowledge using VENUS Visual Basic C MATLAB Python or related languages.
• Must be able to obtain and maintain a Federal or DoD public trust; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred.

What Would Be Nice To Have:

• Background supporting Alzheimers disease or neurodegenerative disease research programs.
• Hands-on work with human stem cell-based disease models.
• Demonstrated ability to develop automated laboratory workflows and assay development methods.
• Strong written verbal analytical organizational and time management skills.
• Ability to work independently and effectively within multidisciplinary research teams.
• Knowledge of microscopy phenotypic screening and image analysis tools.
• Ability to train laboratory staff on scientific instrumentation and automated equipment.
• Contributions to scientific manuscripts publications or related research deliverables.
• Familiarity with NIH federal academic or translational research environments.

What We Offer:

Guidehouse offers a comprehensive total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical Rx Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement Personal Development Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care Hospital Indemnity Accident Insurance Legal Assistance and ID theft protection etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity EmployerProtected Veterans Individuals with Disabilities or any other basis protected by law ordinance or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

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