Associate ScientistScientist I, Bioconjugation 1-Year Contract Position

About Hexagon Bio:

Hexagon Bio leverages a genomics-based platform and understanding of natural product evolution to develop next-generation ADCs with novel payloads for cancer. We use data science genomics machine learning synthetic biology and automation to discover potent evolutionarily refined small molecules from microbial genomes and apply medicinal chemistry to optimize these molecules into truly transformative medicines.

Location: Menlo Park CA

Job description:

Hexagon Bio is seeking a highly motivated Associate Scientist/Scientist I to join our Bioconjugation team. This laboratory-based role focuses on ADC conjugation purification and analytical characterization/QC to support our expanding ADC pipeline. You will work closely with biochemists medicinal chemists and cell biologists to generate high-quality materials that enable in vitro and in vivo studies of novel natural-productbased payloads.

We are looking for a team member who excels at hands-on bench work enjoys solving technical problems and thrives in a fast-paced startup environment. This is a 100% on-site lab-based role.

Key Responsibilities:

• Perform antibody-drug conjugation at milligram scale using a variety of linker chemistries and conjugation strategies
• Purification of conjugated antibodies via FPLC-based purifications (SEC IEX HIC and other chromatography-based methods) and diafiltration.
• Optimize reaction conditions monitor conjugation efficiency and ensure consistency across production batches.
• Execute analytical assays to assess ADC properties and quality including: SEC HIC IEX RP-HPLC UV-Vis LC-MS DAR determination and endotoxin.
• Collaborate with cell biology teams to ensure materials meet criteria for potency assays in vitro MoA studies and in vivo PK/efficacy/tolerability experiments.
• Maintain detailed electronic laboratory notebooks.
• Comply with safety policies and best laboratory practices.
• Contribute to a collaborative transparent and mission-driven team culture.

Requirements:

• Ph.D. 0 to 2 years of relevant experience Masters Degree 3 to 5 years of relevant experience or Bachelors Degree 6 years of relevant experience in Biochemistry Chemistry Structural Biology or related discipline with hands-on experience preferably in protein sciences or related area.
• Direct experience with ADC conjugation protein purification or analytical characterization is strongly preferred.
• Hands-on experience with HPLC based analytical methods such as SEC IEX HIC RP-HPLC and UV-Vis.
• Strong analytical and troubleshooting abilities.
• Excellent organization communication and documentation skills.
• Curiosity initiative and the ability to excel in a dynamic startup environment.

What We Offer:

• A flexible and dynamic work environment where you pave your own path Hexagon cultivates employees unique strengths at all levels and provides mobility across departments.
• All Hands Meetings provide an opportunity to share company and team updates. These meetings are rooted in our value of transparency. They are designed to foster a culture of collaboration curiosity and open communication.
• Rapid career advancement for driven performers.
• Access to scientific conferences throughout the year.
• A range of amenities courtesy of the Menlo Park Labs business park including shuttle gym rock-climbing wall pool sauna sports courts cafe bike lockers and free EV charging stations.
• Opportunities to engage with the Hexagon community through team-building events like our Hexagon Happy Hours and holiday parties.

Additional Information:

The salary range is dependent on the level that is hired. The salary range for this position is $110000 - $140000. Our salary ranges are determined by role level and location. The range displayed on each job posting reflects the minimum and maximum target for new hire salaries for the position across California locations. Within the range individual pay is determined by work location and additional factors including job-related skills experience and relevant education or training.

Hexagon Bio is an equal opportunity employer and committed to a diverse workplace. All applicants will be considered equally without regard to race color ethnicity veteran status religion national origin marital status political affiliation age sex sexual orientation disability status membership in an organization or any other non-merit factors

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.