Associate Scientist, Research Laboratory Operations

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The companys RAS(ON) inhibitors daraxonrasib (RMC-6236) a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291) a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805) a RAS(ON) G12D-selective inhibitor; and RMC-5127 a RAS(ON) G12V-selective inhibitor are currently in clinical development. As a new member of the Revolution Medicines team you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

Revolution Medicines is seeking an individual with a strong background in rodent laboratory animal research. The position will receive study designs from scientists and independently execute in vivo pharmacology studies in mice while demonstrating excellent communication and coordination across addition this role will support vivarium management including management of weekend staff to ensure uninterrupted in vivo operations during weekends and holidays.

• Plan conduct analyze and report in vivo studies (efficacy PK/PD).

• Carry out pre-clinical model development and characterization.

• Manage and supervise multiple research associates.

• Conduct standard vivarium operations-managing inventory/supplies maintain laboratory equipment and record keeping.

• Contribute to continuous improvement of current SOPS and ensure that the appropriate SOPs are followed by all Vivarium users.

• Support adherence to animal welfare guidelines and regulations.

• Learn and conduct other in vivo related techniques.

• Train junior team members on in vivo techniques

• Interface with cross-functional project team members and participation in and presentation at project team meetings and cross-departmental team meetings.

• Formulate and administer drugs and experimental compounds by various routes.

• Troubleshooting issues with the facility animal welfare or executing in vivo procedures.

Required Skills Experience and Education:

• BS or MS in Biology or Pharmacology related discipline (or 5 - 8 years of relevant experience).

• Proficiency with various mouse handling techniques including dosing (IV PO SC IP) tumor inoculation/measurements in life and terminal blood collection survival surgeries and handling of tissues during necropsy and processing for ex vivo analysis.

• Computer literacy especially proficiency with GraphPad Prism Excel PowerPoint and Word.

• Research experience with mouse models of cancer and/or cancer immunotherapy.

• Excellent organizational and communication skills along with the ability to work effectively in a multidisciplinary team environment.

• The ability to work independently on day-to-day responsibilities and research goals.

Preferred Skills:

• Experience with Studylog Prism and Benchling.

• Rodent Surgical Experience.

• Sterile tissue culture.

• Familiarity with sample collection for IHC and cellular biology assays such as: FACS western blot and qPCR.

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