Associate Principle Scientist, Immunopeptidomics

At AstraZeneca we work together across global boundaries to make an impact and find answers to challenges.We do this with theupmostintegrity even in the mostdifficult situationsbecause we are committed to doing the right thing. We continuously forge partnerships that help pursue world-class medicines in new ways combining our peoples exceptional skills with those of people from all over the globe. As a part of our Dynamic Omics team in Gaithersburg MDyoullplay a pivotal role in channeling our scientific capabilities to make a positive impact on changing patients lives.

About AstraZeneca in Gaithersburg MD

Our Gaithersburg Maryland facility creates life-changing medicines for people around the world. This campus employs more than 3500 experts in our field and is only a short drive from Washington DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here we play host to some of the mostcutting-edgetechnology and lab spaces all designed to inspire collaboration and cross-functional science. We believe employeesbenefitfrom being challenged and inspired at work. We are dedicated to creating a culture of inclusion and collaboration.

Summary of the Group

Dynamic Omics is part of the Centre for Genomics Research (CGR) and Discovery Sciences withinAstraZeneca andworks across all therapeutic areas. The Dynamic Omics team delivers key data to projects across all phases ofthe drugdiscovery and development and we work with all modalities from small molecules to biologics.As a member of Dynamic Omics and CGR you will serve as the scientific leader forimmunopeptidomics driving the analysis of preclinical and clinical samples using advanced MHC peptide isolation workflows high-throughput mass spectrometry and specialized bioinformatics pipelines.

We are looking for an expertimmunopeptidomicsscientist who can identify opportunities and synergies across projects and act as a scientific leader influencing across disciplines and therapeutic areas.The successful candidate will be an emerging leader within the AstraZeneca scientific community contributing strategic scientific insight and mentoring junior scientists. Applicants shouldpossessoutstanding written and oral communication skills a strong publication record in high-quality peer-reviewed journals and a demonstrated ability toinitiateand manage internal and external collaborations.

Main Duties and Responsibilities:

• Scientific Leadership: Lead all aspects of mass spectrometry-basedimmunopeptidomics from sample preparation through data acquisition analysis and biological interpretation. Serve as the recognized internal expert and key point of contact forimmunopeptidomics.

• Therapeutic Area Partnership & Collaboration: Driveimmunopeptidomicsprojects in close partnership with the Infectious Disease Therapy Area applying MHC peptide profiling to support antigen characterization target prioritization and vaccine development programs. Representimmunopeptidomicscapabilities to stakeholders form cross-functional project teams and manage external collaborations as needed.

• Method Development: Developoptimize and implement novelimmunopeptidomicsworkflows including MHC class I and class II peptide isolation and advanced LC-MS/MS acquisition strategies ontimsTOFand/or Orbitrap-based systems.

• Data Analysis & Bioinformatics: Leadimmunopeptidomicsdata analysis pipelines includingde novosequencing DIA-based quantification and MHC binding prediction. Apply AI and machine learning tools to enhance data interpretation. Integrateimmunopeptidomicsdata with multi-omics datasets.

• Mentorship:Providescientific guidance to junior scientists and technical staff contributing to team development and a collaborative culture.

• Publications & External Visibility:Maintainan active publication record in high-quality peer-reviewed journals and represent AstraZeneca at international conferences.

Education & Experience Requirements:

• Education: PhD in analytical chemistry biochemistry immunology proteomics ora relevantdiscipline.
• Experience: PhD with 5 years of extensive relevant scientific experience inimmunopeptidomicsor closely related mass spectrometry-based fields with a demonstratedtrack recordof independent project delivery and scientific leadership.

Required Skills

• ImmunopeptidomicsExpertise: Deepexpertisein all aspects of MHC peptideimmunopeptidomicsworkflows including MHC class I and/or class II peptide isolation from cells tissues and biofluids and mass spectrometry-based identification and quantification of immunopeptidomes.

• Mass Spectrometry: Extensive hands-on experience with high-resolution LC-MS/MS platforms (timsTOFand/or Orbitrap-based systems) including method development optimization and troubleshooting.

• Data Analysis & Bioinformatics: Provenexpertiseinimmunopeptidomicsdata analysis approaches includingde novosequencing MHC binding prediction and integration of multi-omics datasets to derive biological insight. Ability to evaluate and apply AI and machine learning tools toimmunopeptidomicsresearch problems.Proficiencyin programming languagesfor custom data analysis visualization and pipeline development.

• Scientific Leadership:Demonstratedability to lead projects from conception through execution data interpretation and publication with limited supervision.Track recordof delivering significant projectobjectivesand influencing scientific direction across disciplines.

• Collaboration & Communication: Proven ability toinitiateand manage internal and external collaborations form cross-functional teams and effectively communicate complex scientific concepts to diverse audiences. Experience conducting scientific briefings and meetings for internal and external representatives.

• Publication Record: Strong publication record in high-quality peer-reviewed journalsdemonstratingscientific impact inimmunopeptidomicsor related fields.

• Mentorship: Experience mentoring junior scientists and contributing to team development.

Desired Skills

• Experience applyingimmunopeptidomicsto support drug discovery programs including target identification antigen presentation profiling or therapeutic response monitoring.

• Expertisein high-throughput and automatedimmunopeptidomicsworkflows.

• Background in immuno-oncology cancer immunology or vaccine antigen discovery.

• Knowledge of MHC biology antigen processing and presentation pathways and T-cell immunology.

• Experience implementing or fine-tuning AI/machine learning models for peptide-MHC interaction prediction immunopeptidome analysis or related applications.

• Experience with automated sample handling and liquid handling platforms.

Why AstraZeneca

At AstraZeneca when we see an opportunity for change we seize it and make it happen because any opportunity no matter how small can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognizing their potential. Join us on our journey of building a new kind of organization to reset expectations of what a biopharmaceutical company can be. This meanswereopening new ways to work pioneeringcutting edgemethodsand bringing unexpected teams together.Interested Come and join our journey.

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