ADME Scientist, Antibody–Oligonucleotide Conjugates (Principal Scientist III)

Job Description Summary

#LI-Onsite
Location: San Diego California

Novartis is seeking a highly motivated ADME scientist for a laboratory-based role supporting the discovery and early development of antibodyoligonucleotide conjugates including antibody-siRNA and antibody-PMO modalities. The successful candidate will bring hands-on experimental expertise in biotransformation biological sample preparation immunoprecipitation/affinity capture LC-MS-based characterization and in vitro/in vivo ADME workflows to enable data-driven candidate selection and translational decision-making.

Job Description

Key responsibilities

• Develop and execute fit-for-purpose ADME and biotransformation workflows for antibodyoligonucleotide conjugates in biological matrices.

• Apply immunoprecipitation and affinity-capture methods to enrich antibody-conjugated species from plasma tissue and cellular samples.

• Use LC-MS/MS and high-resolution MS approaches to assess conjugate integrity stability biotransformation and tissue biodistribution.

• Independently design troubleshoot and interpret in vitro and in vivo studies linking laboratory findings to PK/PD and candidate selection decisions.

• Provide ADME input to project strategy and translational decision-making in collaboration with discovery and development teams.

• Prepare clear study plans technical reports project summaries regulatory content and internal scientific presentations.

• Resolve assay and workflow challenges through practical solutions that improve data quality throughput and scientific impact.

• Ensure high standards of laboratory documentation data integrity safety and compliance with Novartis procedures.

• PhD MSc or BSc in pharmaceutical sciences biochemistry analytical chemistry pharmacology molecular biology bioengineering or a related discipline with relevant industry experience in ADME DMPK biotransformation or biologics/new modality research.

• Demonstrated hands-on laboratory experience with immunoprecipitation affinity capture biological sample preparation and LC-MS/MS or HRMS-based workflows is required.

• Strong understanding of ADME principles and their application to new modalities including oligonucleotides antibody conjugates biologics or other complex therapeutics.

• Experience developing or executing LC-MS/MS or HRMS-based methods to characterize metabolic stability biotransformation and molecular fate of antibodyoligonucleotide conjugates.

• Ability to work effectively in a cross-functional matrixed project environment and communicate complex scientific data clearly to project teams.

• Strong organizational skills attention to detail scientific rigor and ability to manage multiple studies and priorities.

• Fluent oral and written English.

• Experience with antibodyoligonucleotide conjugates antibody-siRNA conjugates antibody-drug conjugates therapeutic proteins or other targeted delivery platforms.

• Knowledge of oligonucleotide metabolism nuclease-mediated degradation linker stability conjugate heterogeneity and tissue distribution challenges.

• Experience with biological sample preparation from plasma tissue homogenates cells or subcellular fractions.

• Familiarity with ligand-binding assays hybridization-based assays ligand capture LC-MS workflows proteomics or intact/protein-level mass spectrometry.

• Experience with laboratory automation liquid handling assay miniaturization or higher-throughput sample preparation.

• Experience contributing to IND/IMPD-enabling packages regulatory documentation or project transition reports.

This is a dual posting. The final level & title of the offer role would be determined by the hiring team based on the skills experience & capabilities required to perform the role at the level the role has been offered.

The salary for this position is expected to range between:

Principal Scientist I: $108500 and $201500 per year.
Principal Scientist II: $119700 and $222300 per year.

The final salary offered is determined based on factors like but not limited to relevant skills and experience and upon joining Novartis will be reviewed periodically. Novartis may change the published salary range based on company and market factors.

Your compensation will include a performance-based cash incentive and depending on the level of the role eligibility to be considered for annual equity awards.

US-based eligible employees will receive a comprehensive benefits package that includes health life and disability benefits a 401(k) with company contribution and match and a variety of other addition employees are eligible for a generous time off package including vacation personal days holidays and other leaves.

To learn more about the culture rewards and benefits we offer our people click here.

EEO Statement:

The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment hiring training promotion or other employment practices for reasons of race color religion sex national origin age sexual orientation gender identity or expression marital or veteran status disability or any other legally protected status.

Accessibility and reasonable accommodations

The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If because of a medical condition or disability you need a reasonable accommodation for any part of the application process or to perform the essential functions of a position please send an e-mail to or call 1 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.

Salary Range

$108500.00 - $201500.00

Skills Desired

Chemistry Clinical Pharmacology Clinical Research Medical Research Patient Care Physiology Simulation Software Translational Medicine