Synthetic Organic Chemistry Contractor (1 year)

Monte Rosa Therapeutics is seeking a highly motivated and innovative synthetic chemist to contribute to the advancement of our molecular glue degrader (MGD) platform. This role is ideally suited to a scientist with deep expertise in synthetic organic chemistry and a strong track record in developing novel methodologies to access differentiated chemical space.

Working within a highly collaborative and interdisciplinary environment you will play a key role in designing and expanding proprietary small-molecule libraries to support the discovery of transformative therapies. The position calls for scientific creativity technical excellence and the ability to bridge cutting-edge synthetic chemistry with modern medicinal chemistry principles.

Design and develop innovative small-molecule libraries targeting previously undruggable proteins using MGD approaches
Act as a key driver in the evolution of the chemistry platform through the development of novel synthetic methodologies and reaction design
Plan and oversee synthesis strategies executed through a global CRO network
Integrate biological data (ADME pharmacology) to inform compound design and optimization
Collaborate closely with multidisciplinary teams (chemistry biology computational sciences) to ensure timely delivery of project milestones
Strengthen technical capabilities to enhance innovation and efficiency
Document and communicate scientific findings through internal reports patents and peer-reviewed publications

PhD in Synthetic Organic Chemistry; postdoctoral experience in academia or industry is preferred
Strong expertise in complex molecule synthesis and/or reaction and methodology development
Demonstrated track record of scientific impact through publications and/or patents
Solid understanding of medicinal chemistry principles and their application in drug discovery
Experience in parallel synthesis would be advantageous
Experience with CRO collaborations is advantageous but not essential including exposure to outsourced synthesis strategies
Sound understanding of preclinical drug discovery including ADME and developability considerations
Familiarity with chemical databases visualization tools and molecular modelling (e.g. Maestro)
Awareness of emerging discovery modalities (e.g. DEL direct-to-biology approaches)
Excellent interpersonal and communication skills with the ability to foster effective scientific collaboration
Proactive forward-thinking mindset with a strong interest in innovation and continuous development