Senior Director, Economic Modeling

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The companys R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The companys RAS(ON) inhibitors daraxonrasib (RMC-6236) a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291) a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805) a RAS(ON) G12D-selective inhibitor; and RMC-5127 a RAS(ON) G12V-selective inhibitor are currently in clinical development. As a new member of the Revolution Medicines team you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway.

The Opportunity:

The Senior Director of Economic Modeling is responsible for defining and executing the economic modeling strategy to produce high quality health economic models & modeling strategies across Rev Meds portfolio. This is an exceptional opportunity to contribute to the advancement of healthcare by providing evidence that can shape the future of patient care in Oncology.

Key Strategic Responsibilities:

• Lead the development of strategic and operational plans for health economic modeling within Global HEOR & RWE (e.g. early and submission cost-effectiveness / utility models budget impact models and country adaptations) while ensuring alignment with Integrated Evidence Plans and appropriate Global stakeholders.

• Partner with Global HEOR & RWE Executive Directors on core health economic modeling plans to support HTA payer and other access stakeholder assessments submissions negotiations including associated value/HTA deliverables and publications to meet business and access objectives.

• Provide strategic methodological and analytical leadership to teams and countries for adaptation of economic models for local HTA submissions.

• Lead the development of an approach to monitor educate and integrate evolving HTA guidelines payer requirements and methodologic advancements related to economic modeling.

• Lead the development of robust governance compliance and readiness for all economic modeling activities by adhering to processes guidelines and project management standards.

• Represent Rev Med in global external working groups regarding modeling standards and innovation (e.g. ISPOR Special Interest groups).

Key Operational Responsibilities:

• Support design and development of economic models from start to finish for products across Rev Meds portfolio.

• Direct statistical analyses of real-world data and clinical trial data (in collaboration with biostatistics) to generate inputs including treatment effects survival extrapolations resource use and health utility estimates.

• Design evidence synthesis including network meta-analysis (NMA) and matching adjusted indirect comparisons (MAIC) to inform comparative effectiveness.

Required Skills Experience and Education:

• Advanced degree (Masters or PhD) in health economics econometrics biostatistics mathematics engineering or related field (DrPH PharmD).

• Minimum of 15 years with a Masters (or 13 years with a PhD/PharmD/DrPH) of relevant experience in economic modeling in the pharmaceutical biotech or consulting setting.

• Hands on experience in developing cost-effectiveness budget impact models as well as NMA/MAIC.

• Track record of high impact publications in economic modeling for global access decision-makers.

• Experience supporting HTA submissions and payer evidence generation.

• Strong written and interpersonal communication skills with an ability to present complex technical information clearly.

• Proven leadership and ability to influence others without direct reporting relationships.

• Comfortable working in a global team across time zones.

Preferred Skills:

• Experience in oncology economic modeling is highly desirable especially related to gastrointestinal and thoracic malignancies.

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