Thesis Work, 3045 Credits – Generation and Optimization of 3D Kidney Organoids for Assay Development

Are you passionate about stem cell biology and advanced in vitro modeling Join our team for a Masters thesis project focused on developing and optimizing iPSC-derived 3D kidney organoids to support drug discovery. You will gain hands-on experience in stem cell culture differentiation protocols immunocytochemistry advanced imaging and image analysis and qPCR while contributing to the creation of robust disease-relevant kidney models for mechanistic studies and assay development.

About AstraZeneca
AstraZeneca is a global science-led patient-focused biopharmaceutical company focusing on discovering developing and commercializing prescription medicines for some of the worlds most serious diseases. But were more than a global leading pharmaceutical company. At AstraZeneca were dedicated to being a Great Place to Work and empowering employees to push the boundaries of science and fuel their entrepreneurial spirit.

About the Opportunity
As a Thesis Worker at AstraZeneca youll find an environment thats full of unique opportunities and exciting challenges. Here youll have the opportunity to pursue your areas of interest whilst equally developing a broad skillset and knowledge base to get the best out of your experience. Youll be working on meaningful projects to make an impact and deliver real value for our patients and our business.

Thesis Work Description
This project aims to develop and optimize culture conditions for iPSC-derived 3D kidney organoids by systematic design of experiments (DoE). The student will help refine media formulations extracellular matrices and key culture parameters to establish robust and reproducible workflows for kidney organoid generation.
Hands-on work will include stem cell culture kidney organoid differentiation immunocytochemistry advanced imaging and image analysis and qPCR. The optimized system will be validated using disease-relevant perturbations such as loss-of-function approaches and kidney injury stimulation to assess model fidelity robustness and translational relevance.

Key Objectives

• Optimize culture conditions using DoE and automation: Establish an efficient and reproducible workflow for refining media extracellular matrix and environmental factors for kidney organoid culture.
• Develop a quality control framework: Define quality standards for cross-plate and cross-experiment consistency to support robustness and reproducibility in downstream research applications.

Your work will help establish advanced in vitro kidney organoid models for disease mechanism studies and high-throughput biology.

Location
This is an on-site position at AstraZeneca in Gothenburg Sweden.
AstraZeneca does not support with accommodations for this role.

Project Structure

• Duration: Start Nov 2026/Jan 2027
• Credits: 30/45

Essential Requirements

• Enrolled in a Masters program in a Swedish University in cell biology biomedical science molecular biology biotechnology or another relevant field.
• Strong interest in stem cell biology advanced invitro models and translational assay development.
• Detail-oriented independent collaborative curious and comfortable solving scientific problems.
• Experience with cell culture is essential; experience with complex 3D models is preferred.

So whats next
Apply today and take the chance to be part of making a difference making connections and gaining the tools and experience to open doors and fulfil your potential. We cant wait to hear from you!
We welcome your application as soon as possible but ahead of the scheduled closing date 22nd of September 2026. In the event that we identify suitable candidates ahead of the scheduled closing date we reserve the right to withdraw the vacancy earlier than published.

Date Posted

Closing Date