Research assistant in Tranlational Pharmacokinetics and Pharmacodynamics

The Department of Pharmacy at Uppsala University has an interdisciplinary environment at the center of the pharmaceutical arena. With frontline research first-rate education and extensive collaborations we constitute a driving force in the development of our academic this inspiring environment our rich diversity of research groups several of international prominence develop and conduct work of great scientific importance. Among our core competencies are computational modelling and simulations PKPD in vitro ADME models advanced in vivo methods biological medicines as well as patient and societal aspects from optimising the use of drugs in individuals to societal pharmaceutical policies. Together we form a unique cluster of academic competencies within pharmaceutical science playing a key role in shaping the future of pharmacy in both Sweden and globally.

Our scientific focus areas include:
Pharmacokinetics & Pharmacodynamics Pharmacometrics Clinical Pharmacy Advanced Drug Delivery Molecular Pharmaceutics Biological Drugs Pharmacoepidemiology Social Pharmacy

More information

Tasks: The project will involve investigation of biomarkers of chemotherapy-induced peripheral neuropathy (CIPN) with a focus on serum neurofilament light chain and the role of barriers of the central and peripheral nervous system in the development of CIPN. Data generated experimentally will be used for pharmacokinetic-pharmacodynamic modeling as a translation tool to characterize the relationship between the exposure of chemotherapeutic agents in plasma/CIPN sites and biomarkers in the serum. Chemotherapeutic agents will include several microtubule targeting drugs and antibody-drug conjugates.

Qualifications: The applicant must have a masters degree in pharmaceutical medical engineering/natural science or a related field. Applicants must have documented experience in animal studies related to chemotherapy-induced peripheral neuropathy UPLC-MS/MS drug bioanalysis NfL bioanalysis and pharmacokinetic-pharmacodynamic modeling&simulation.

We place great emphasis on personal suitability as well as motivation and interest in improving the safety of anticancer drugs. The applicant must be able to express him/herself well both orally and in writing in English. Applicants must be able to work independently and in a group.

Merit: Understanding of the structure and function of barriers of the central and peripheral nervous system. Basic understanding of pharmacokinetics of antibody-drug conjugates. Hands-on experience in pharmacokinetic-pharmacodynamic data analysis and modeling. Interest in and skill in scientific writing in English is highly desirable.

About the employment
The employment is a temporary position 4 months. Scope of employment 100%. Starting date 1 September 2026 or as agreed. Placement: Uppsala

For further information about the position please contact: Associate Professor Irena Loryan

Please submit your application by 12 August2026 UFV-PA 2026/2374.

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