Research assistant in new treatment development for Alzheimer disease

The project is integrated into the research group of Lars Tjernberg which focuses on investigating disease mechanisms in Alzheimer disease and developing novel therapeutic strategies. The group consists of senior researchers postdoctoral researchers and students and offers a methodologically broad interprofessional and supportive research environment. We have established an integrated research pipeline encompassing mechanistic studies compound design and screening in vitro verification and evaluation in cellular and animal models. We aim to use these platforms to elucidate the degradation mechanisms of pathological proteins and leverage this knowledge for the development of protein-targeted degraders for Alzheimers disease.

We are seeking a motivated Research Assistant to support ongoing in vitro experiments investigating Tau-targeted degraders for Alzheimers disease and establishing high-throughput screening assays. Your main responsibilities will include:

• Brain dissection and primary neuronal culture
• Compound evaluation in cell models with tau pathology
• Establishment of high-throughput screening assay and verification
• Maintaining accurate experimental records data analysis and management
• Manuscript writing

This is a full-time (100%) fixed-term position for 5 months. This position offers the opportunity to contribute to an active research project and gain practical experience in new drug discovery and development in Alzheimer disease.

We are looking for a highly motivated candidate with a strong interest in research and the ability to collaborate and work effectively within a team.

Requirements for the position

• Masters degree in biomedicine neuroscience molecular biology or a related life science discipline
• Practical laboratory experience including primary neuron culture western blot plasmid construction and transfection flow cytometry and immunofluorescence.
• Training in laboratory animal science according to FELASA guidelines (or equivalent training for handling experimental animals).
• Ability to work both independently and collaboratively in a research environment.
• Good communication skills in English

Merits for the position is also experience of

• Compound evaluation
• Drug delivery system
• Studies of protein-protein interactions

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the worlds leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities where trained staff are on site.

Location: Solna

Choose to work at KI Ten reasons why

KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T.

The application is to be submitted through the Varbi recruitment this recruitment you will apply with your CV without a personal letter. Instead you will answer some questions about why you are applying for the job in the application form.

Permanent position is initiated by a six months trial period.

The Department of Neurobiology Care Sciences and Society (NVS) conducts world leading research in aging dementia epidemiology and care sciences. This research extends from basic molecular and cell levels to clinical research and societal studies. NVS educates almost a third of KI students at basic and advanced levels. The Department has approximately 540 employees and a revenue 2025 of 580 million SEK. It comprises seven divisions located at Campus Flemingsberg and Campus Solna.

The Division of Neurogeriatrics consists of about 65 employees. The division conducts experimental and translational research related primarily to Alzheimers disease and other neurodegenerative diseases but also more general molecular mechanisms with biomedical relevance are studied. The division is mainly located in BioClinicum KI Campus Solna and partially in Neo KI Campus Flemingsberg.