Postdoctoral Researcher in multi-omic bioinformatics in Multiple Sclerosis

Join the dynamic and cooperative team and group led by Assoc. Prof. Lara Kular and Prof. Maja Jagodic at the Department of Clinical Neuroscience. We are physically located at the Center for Molecular Medicine a translational medical center with 500 researchers working on complex diseases and with extensive national and international collaborations. The Functional (Epi)genomics of Neuroinflammatory Diseases group is part of the Karolinska Neuroimmunology and Multiple Sclerosis (KNIMS) network which gathers around 90 researchers working on different aspects of the pathogenesis of Multiple Sclerosis (MS) and other neuroinflammatory diseases including genetics epidemiology immunology and epigenetics with excellent clinical cohorts and experimental models. This position offers the opportunity to contribute to interactive research driven by pertinent clinical questions combining deep molecular understanding of the mechanisms underlying Multiple Sclerosis (MS). You will benefit from a highly collaborative engaged and international research environment where you will have the possibility to conduct research at the top international level in the field.

We are looking for a candidate who has a PhD in bioinformatics computer science data analysis or similar field. The successful candidate will join our research team and collaborate with PhD students postdocs and senior researchers to decipher multiple sclerosis pathogenesis with a focus on the mechanisms underlying the impact of smoking-induced lung inflammation in MS.

The work entails analysis of omic data and multi-omic integration from bulk next-generation sequencing transcriptomic (coding and non-coding RNA-seq) methylomic (Illumina array and EM-seq) data with possibility to analyze single-cell data.

To be eligible for employment as a postdoctoral researcher a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons your degree may have been completed earlier.

We are looking for an intelligent creative hardworking and enthusiastic team player who shares our passion for translational research is ready to join our collaborative team and perform computational work. The candidate is expected to actively lead computational work and participate in scientific writing and presentations. The applicant should also be committed to maintaining a friendly and productive work environment. Of note a genuine personal letter composed without AI-assistance can favourably impact evaluation/final ranking.

Requirements

The following criteria are essential:

• PhD in life sciences in the field of computational science/biology
• Solid programming proficiency especially in R Python and Linux-based software
• Demonstrated skills in array/sequencing-based omics data processing analysis visualization and interpretation
• Documented experience in multi-omic integration
• Documented knowledge of statistics
• Experience with high-performance computing using clusters like UPPMAX
• Ability to demonstrate good inter-personal and communication skills
• High proficiency in spoken and written English

• Scientific and/or research background on human diseases and mechanisms involved in autoimmunity lung biology and/or inflammation.
• Knowledge of mechanisms of gene regulation and epigenetics including DNA methylation non-coding RNA biology.
• Ability to work independently as well as in collaboration with colleagues and students in an interdisciplinary research environment.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the worlds leading medical universities. At Karolinska Institutet we conduct successful medical research and hold the largest range of medical education in Sweden. At KI you get to meet researchers working with a wide range of specialisms and methods giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations which have pushed KI to where it is today at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university which entitles you to several benefits through our collective agreement.

Location: Solna

Read more about Department of Clinical Neuroscience
Read more about the research group you will be part of

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé including date of the thesis defence title of the thesis previous academic positions academic title current position academic distinctions and committee work
• A complete list of publications
• A summary of current work (no more than one page)

KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T

The application is to be submitted through theVarbi recruitment system.