Postdoctoral position in CNS regeneration

The Llorens laboratory offers a vibrant stimulating and international environment. We are part of the Department of Cell and Molecular Biology at the Karolinska Institute in Stockholm Sweden one of the worlds leading medical universities. The lab is located in Biomedicum one of Europes largest laboratories with ultramodern facilities and rich opportunities for collaboration and career development.

Our lab is interested in stimulating regeneration in the mammalian central nervous system (CNS). We aim to uncover the principles of cell fate regulation during development and repurpose them for regeneration. We use a multidisciplinary approach that involves glial and stem cell biology genomics computational biology and animal models of disease.

Using single cell multiomics we recently discovered a latent regenerative potential in adult spinal cord stem cells and designed a targeted intervention to elicit such potential. This intervention stimulated endogenous remyelination and improved axon conduction after injury (Llorens-Bobadilla et al. Science 2020). These studies suggest that activating the right endogenous genes after injury could unlock the dormant regenerative potential of resident stem cells.

The current projects aims to systematically screen and identify pro-regenerative genes through comparative analyses of glia-mediated CNS repair and systematic in vivo perturbations.

Link to the lab website: mission

We are seeking a driven and enthusiastic postdoctoral fellow to perform comparative studies on CNS repair using novel spatial genomics technologies and in vivo perturbations to ultimately identify pro-regenerative strategies in the injured CNS.

We are looking for highly motivated independent and self-driven candidates with a strong track record and relevant experience during the PhD. The successful applicant is expected to have a background and a strong interest in one or several of the following areas: glial biology molecular neuroscience single cell and spatial genomics gene delivery animal models of CNS injury or disease. A documented ability to independently carry out experimental research projects is required as are good communication skills in spoken and written English. Experience with molecular engineering CNS injury models across species viral gene delivery and/or bioinformatics will be considered an advantage.

To be eligible for employment as a postdoctoral researcher a PhD or a foreign degree deemed to be equivalent to a Swedish PhD is required. This eligibility requirement must be fulfilled at the latest at the time of the employment decision. Completion of your doctoral degree within the last three years is considered an advantage. If there are special reasons your degree may have been completed earlier.

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the worlds leading medical universities. At Karolinska Institutet we conduct successful medical research and hold the largest range of medical education in Sweden. At KI you get to meet researchers working with a wide range of specialisms and methods giving you ample opportunity to exchange knowledge and experience with the various scientific fields within medicine and health. It is the crossover collaborations which have pushed KI to where it is today at the forefront of global research. Several of the people you meet in healthcare are educated at KI. A close relationship with the health care providers is important for creating groundbreaking top quality education and research. Karolinska Institutet is also a state university which entitles you to several benefits through our collective agreement.

Location: Solna

An employment application must contain the following documents in English or Swedish:

• PhD certificate
• A complete resumé including date of the thesis defence title of the thesis previous academic positions academic title current position academic distinctions and committee work
• A complete list of publications
• A summary of current work (no more than one page)

• Names of three references

KI applies individual and differentiated salary setting in accordance with our collective agreements RALS and RALS-T

The application is to be submitted through the Varbi recruitment system.