Senior Clinical PBPK Modeling Scientist
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Monthly Salary:
Posted:
Application Deadline:
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Job Summary
The ideal candidate will havestrongbackground in pharmacokinetics and translational modeling. You willparticipatein implementing innovative and quantitative approaches to advance clinical drug development.Developing qualifying and applying mechanistic PBPK modelsusing invitro preclinical clinical and literature data to support clinical development decisions across therapyareas.In addition you will have opportunities to contribute to broader areas within Clinical Pharmacology & Quantitative Pharmacology(CPQP)asperyour experience interestsandexpertisedictate.
Typical Accountabilities
Utilizephysiologically-basedpharmacokinetic (PBPK)and translational modeling tools to enable clinical PK projections fordrug-drug interactions (DDIs) pediatric and other specific populations and other clinical development questions
Collaborate withDrug Metabolism and Pharmacokinetic (DMPK) Scientistsand Clinical Pharmacology scientists to generate these mechanistic models
Develop fit-for-purpose qualified PBPK models suitable for internal decision-making and regulatory use including support forsubmissiondocumentation and health authorityinteractions.Communicateclearly and effectively both internally and externally on topics related to PBPK clinical DDI and pediatric and other specific populations predictions
Keep up to date with emerging literature modeling science and regulatory expectations
Education QualificationsSkillsand Experience
Essential
PhD degree preferred or equivalent (./Pharm.D.)
Experience using PBPK platforms such asSimcypGastroPlus or PK-Sim together with scripting in R and/or Python for data analysis visualization and workflow automation.
Familiarity with AI-enabled scientific workflows such as literature mining codingassistance or document summarization in compliant research environments
Demonstrated broadPBPKexpertiseand experience exemplified by1-4Years of drug development experience with emphasis onPBPK modelling
Goodknowledge inpharmacokinetics drug-drug interactions regulatory guidance in clinical pharmacologymodellingand simulation sciences
Demonstrated ability toidentifydevelopand executePBPKactivitiesat a project level
Goodoral and written communication skills
Good knowledge of global regulatory compliance processesstandardsand issues specific toPBPK
with relevant experience
Experience authoring or contributing to PBPK technical reports and regulatory documentation including submission-ready analyses and responses to health authority queries.Fluency in spoken and written English language
Desirable
Areputation gained from scientific publishingin the field of DMPK/Clinical Pharmacology
Experience inearly andlate-stagedrug development
Date Posted
03-jul-2026Closing Date
16-jul-2026AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds with as wide a range of perspectives as possible and harnessing industry-leading skills. We believe that the more inclusive we are the better our work will be. We welcome and consider applications to join our team from all qualified candidates regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment) as well as work authorization and employment eligibility verification requirements.
Required Experience:
Senior IC
About Company
AstraZeneca is an equal opportunity employer. AstraZeneca will consider all qualified applicants for employment without discrimination on grounds of disability, sex or sexual orientation, pregnancy or maternity leave status, race or national or ethnic origin, age, religion or belief, ... View more
