Scientist Chemistry (bachelormaster)

Developing future oncology medicines through hands-on medicinal chemistry.

Within our Medicinal Chemistry department we have an exciting opportunity for a ScientistChemistry who is enthusiastic about hands-on laboratory work and enjoys working closely with colleagues in a collaborative environment. This role offers the chance to apply yourexpertise and to make a real impact on the progress of our projects.

AcertaPharma will berelocatingtoAmsterdam with the current move planned forearly2027. Until that time you will be working from our facilities in Oss. After the move you will be basedatournew sitein Amsterdam.

ScientistChemistry (bachelor/master)

Pivot Park OssAmsterdamUMC campus

Fulltime

Your challenge:

AsaScientistyou willbepart of ourMedicinal Chemistry teamand focus on thesynthesis and analysis of new will be the driving force in the labcontributing to theprogressof our projects towards clinical development.

What will you be doing

• Your main task is tosynthesizenewbioactive substances chemical entitieswithin medicinal with your colleagues youwillimplementnew synthetic routesandprocessesto get tothedesired moleculesmost efficiently.

• You will scale upthe synthesis of interesting analogues from mg to g scale forfurtherin vivotesting.

• Youwill present your workinregularchemistry and project meetings andactively take part in discussingthe chemistryofyourand otherteams.

• You willhavethe opportunity tofamiliarize yourselfwith important conceptsonoptimization of small moleculesfor different modalities in modern Medicinal Chemistry( about the usage of AIandcomputational Chemistry structure-baseddrug designwithin this process).

• Youmaintainahigh qualityandaccurateelectronicnotebook asafeworkingenvironmentandoperateaccordingtoourguidelines on SafetyHealthand Environment.

Whatareyoubringing

• Completedbachelors or masters degree in chemistrywith organic chemistry as aspecialisation(or equivalent).

• Please note that PhD is overqualified for this role.

• At least3years of experience with organic(and/or medicinal)chemistry (synthesis of small organic molecules).

• Experience withstandardanalysis and purification techniquessuch ascolumn chromatography(HP)LC-MS NMR.

• Experience with medicinal chemistry in the pharmaceutical industry is an advantage.

• Youare fluent in English.

• Excellent writtenand communicationskills.

• You enjoy working in a team where each member is supportive and opentohelpingeach other.

Please note that we dont offer a relocation package for this role. You are currently based in the Netherlands or within reasonable commuting distance of the office.

What do we offer you

• A dynamic innovative international working environment where you can be part of the development of new medicines that can make a difference to patients lives

• The opportunity to work withstate-of-the-artequipment and analytical techniques

• The opportunity to grow intomodern Medicinal Chemistry across multiple modalities

• Competitive salary and secondary benefits including 8% holiday allowance 27 holidays on a full-time : office closure between X-mas and New Year Good Friday day after Ascension Day.

• Collective pension with a fixed percentage personal contribution

• Bonus scheme

• Opportunity to participate in our share purchase plan with an additional contribution from AstraZeneca

• Vitalityof our colleagues is important to us which is why you can exercise at a discount or make use of our bicycle plan.

• Support for potential extra travelling costs during the transition period when working at the Oss site

About AstraZeneca Oncology R&D Amsterdam

At AstraZeneca Amsterdam we bring together two research groups in haemato-oncology and next-generation cell therapy research. Together they form our OncologyR&D hub in the Netherlands working closely with colleagues in the US CanadaSpainand the UK to develop innovative treatments for patients with cancer.

Our hematology R&D group was bornas AcertaPharma one of the Netherlands greatest biotech success stories. Its small-molecule BTK inhibitor has been approved by both the US Food and Drug Administration (FDA) and the European Medicines Agency (EMA) for the treatment of Chronic LymphocyticLeukemia(CLL) and Mantle Cell Lymphoma (MCL). In Amsterdam approximately 100 colleagues continue the development of new therapies forhaematologicalmalignancies under the AstraZeneca brand name.

AstraZenecas Cell Therapy R&D team focuses on developing next-generation T-cell receptor (TCR) therapies targeting neoantigens in solidtumors. With a team of around 75 scientists we work on both fullyindividualizedand shared neo-antigen approaches with the aim of improving outcomes for patients with cancer.

Our oncology research and development hub is anchored by our newstate-of-the-artlaboratoriesinOne Helixand the adjacent Plus Ultra Amsterdam building bothlocatedon the Amsterdam University Medical Centre (Amsterdam UMC) campus. Our hub is firmly positioned at the heart of the Dutch research community network creating new opportunities for our people our science and the patients we work to transform outcomes for.

Apply:
If you have any questions about this vacancy our Recruitment Team (KarinRaadscheldersandCaroline van Oppen) are happy to answer your questions. You can contact them via or by phone on 31(0)85 -.

We dont work with a fixed closing date: The vacancy will remain online until we have concluded the process.

Please apply immediately we start up the selection process straight away.

Date Posted

Closing Date

AstraZeneca embraces diversity and equality of opportunity. We are committed to building an inclusive and diverse team representing all backgrounds with as wide a range of perspectives as possible and harnessing industry-leading skills. We believe that the more inclusive we are the better our work will be. We welcome and consider applications to join our team from all qualified candidates regardless of their characteristics. We comply with all applicable laws and regulations on non-discrimination in employment (and recruitment) as well as work authorization and employment eligibility verification requirements.