Postdoc Computational Biology and Omics

• Nijmegen

Retinal diseases such as age-related macular degeneration (AMD) diabetic retinopathy and inherited retinal disorders are leading causes of blindness worldwide. Traditional models (animal or 2D cell cultures) fail to fully replicate the complex structure vascularization and function of the human retina. Retinal organoids-on-chip offer a breakthrough: they recreate 3D retinal architecture allow integration of microvasculature and enable real-time functional studies through electrophysiology. This platform provides an unprecedented window into human retinal disease mechanisms and potential therapeutic interventions.

We invite applications for a postdoctoral researcher to join our interdisciplinary team at the interface of computational biology multi-omics data analysis and systems biology. Our group specializes in integrating high-dimensional omics data with functional electrophysiology from patient-derived stem cell models enabling unique insights into disease mechanisms and cellular function.

Position Overview:

We are seeking a highly motivated researcher with expertise in computational analysis of multi-omics datasets (e.g. genomics transcriptomics proteomics metabolomics) and a strong interest in integrative systems biology approaches. The successful candidate will work on cutting-edge projects that combine multi-omics datasets with electrophysiology measurements from patient-derived stem cell models to explore disease mechanisms cellular regulatory networks and functional phenotypes. This is an exciting opportunity to work in a team that bridges computational analysis with translational experimental validation.

This research will focus on addressing these critical challenges helping to pioneer innovative solutions for vision preservation and restoration.

The candidate will be affiliated at the Department of Ophthalmology and collaborate with the Department of Human Genetics. The candidate will be supervised by Dr. Zohreh Hosseinzadeh.

The Department of Ophthalmology of the Radboud University Medical Center is a global leader in the field of multifactorial and genetic retinal eye diseases. The research of the department is focused on retinal forms of blindness that affect large numbers of patients worldwide especially inherited retinal degenerations (IRDs) such as retinitis pigmentosa and age-related macular degeneration (AMD). Our aim is to develop personalized treatment and prevention options using metabolomics natural history studies and genetic profiles combined with imaging parameters and artificial intelligence.

The Department of Human Genetics is divided in multiple division all well known worldwide. The patient care (division clinical genetics) and genetic diagnostics (division genome diagnostics) performed within our department is hosted by an official and acclaimed Centre for Clinical Genetics. The division genome research performs groundbreaking research into the relationship between genes and diseases as well as therapy development notably concerning blindness and deafness cancer congenital anomalies and mental handicaps. To identify and functionally characterize novel disease genes we utilize a combination of biochemistry genomics technologies molecular biology cell biology and developmental systems such as iPSC model systems Drosophila melanogaster zebrafish and mouse.

Radboudumc is internationally renowned for its research and diagnostics on a variety of genetic disorders and the impact of personalized medicine. The Departments offer an exciting working environment with enthusiastic people from many parts of the world providing ample critical mass and a stimulating collaborative atmosphere for high quality research.