Associate Director, In-Vivo Pharmacology

At RayzeBio every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb RayzeBio blends the nimble pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here youll join a multidisciplinary team where your ideas are valued your expertise is amplified and collaboration is at the heart of everything we do. From day one expect to make an immediate impacton our science on our teams and most importantly on patients. Learn more about RayzeBio: is seeking an Associate Director InVivo Pharmacology to provide scientific and operational leadership across oncology programs with a focus on radiopharmaceutical therapeutics (RPTs). This role provides functional leadership to senior scientists to design and execute highquality invivo studies that inform program strategy from discovery through INDenabling development.

The Associate Director will set direction ensure alignment and drive highquality decisionmaking while maintaining accountability for vivarium operations animal welfare and regulatory compliance (IACUC/AALAC). This is a highly crossfunctional role that operates close to the science without serving as the primary experimentalist. The ideal candidate combines deep expertise in oncology invivo pharmacology with a strong sense of ownership practical decisionmaking and comfort operating at the intersection of science operations and compliance in a fastmoving biotech environment.

Key Responsibilities

• Lead the invivo pharmacology strategy for oncology RPT programs by supporting scientists in study design execution data interpretation and translational relevance.

• Serve as a scientific thought partner providing feedback and direction on: model selection (CDX/PDX) dose and schedule rationale and endpoint definition and evaluability. Support selection of mouse strains tumor models activity levels and fractionation schemes appropriate for Lu177 Ac225 and future RPT isotopes and modalities.

• Ensure consistency rigor and strategic alignment across invivo studies supporting multiple programs from early discovery through INDenabling development.

• Own efficacy and biodistribution strategy for radiopharmaceutical programs incorporating tumor growth kinetics delayed response patterns and modalityspecific considerations. Ensure study designs reflect radiobiological realities.

• Partner closely with dosimetry/physics imaging radiochemistry biology and DMPK teams to align invivo studies with absorbed dose and exposureresponse understanding.

• Review and contribute to invivo pharmacology sections of study reports and INDenabling regulatory submissions.

• Serve as a point of escalation for animal care biosecurity or facilityrelated issues impacting studies and operations.

Education and Experience

• Ph.D. in Pharmacology Cancer Biology Toxicology or related field with 8 years of relevant industry experience

• Strong track record in invivo oncology pharmacology including xenograft efficacy studies and supporting preclinical programs advancing toward IND

• Demonstrated ability to lead complex crossfunctional teams/efforts and make pragmatic decisions in a fastpaced R&D environment

• Working knowledge of IACUC processes animal welfare regulations and experience supporting AALAC accreditation activities

• Experience applying AI and computational tools to enhance data analysis automate routine workflows and support data-driven decision-making is desirable

• Experience with radiopharmaceuticals radioligand therapies or radiationbased modalities including familiarity with biodistribution dosimetry and radiation biology concepts preferred

If you come across a role that intrigues you but doesnt perfectly line up with your resume we encourage you to apply anyway. You could be one step away from work that will transform your life and career.

The starting compensation range(s) for this role are listed above for a full-time employee (FTE) basis. Additional incentive cash and stock opportunities (based on eligibility) may be available. The starting pay rate takes into account characteristics of the job such as required skills where the job is performed the employees work schedule job-related knowledge and experience. Final individual compensation will be decided based on demonstrated experience.

Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits please visit offerings are subject to the terms and conditions of the applicable plans in effect at the time and may require enrollment. Our benefits include:

• Health Coverage: Medical pharmacy dental and vision care.

• Wellbeing Support: Programs such as BMS Well-Being Account BMS Living Life Better and Employee Assistance Programs (EAP).

• Financial Well-being and Protection: 401(k) plan short- and long-term disability life insurance accident insurance supplemental health insurance business travel protection personal liability protection identity theft benefit legal support and survivor support.

Work-life benefits include:

Paid Time Off

• US Exempt Employees: flexible time off (unlimited with manager approval 11 paid national holidays (not applicable to employees in Phoenix AZ Puerto Rico or Rayzebio employees)

• Phoenix AZ Puerto Rico and Rayzebio Exempt Non-Exempt Hourly Employees: 160 hours annual paid vacation for new hires with manager approval 11 national holidays and 3 optional holidays

Based on eligibility* additional time off for employees may include unlimited paid sick time up to 2 paid volunteer days per year summer hours flexibility leaves of absence for medical personal parental caregiver bereavement and military needs and an annual Global Shutdown between Christmas and New Years Day.

All global employees full and part-time who are actively employed at and paid directly by BMS at the end of the calendar year are eligible to take advantage of the Global Shutdown.

*Eligibility Disclosure: The summer hours program is for United States (U.S.) office-based employees due to the unique nature of their work. Summer hours are generally not available for field sales and manufacturing operations and may also be limited for the capability centers. Employees in remote-by-design or lab-based roles may be eligible for summer hours depending on the nature of their work and should discuss eligibility with their manager. Employees covered under a collective bargaining agreement should consult that document to determine if they are eligible. Contractors leased workers and other service providers are not eligible to participate in the program.

RayzeBio and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however RayzeBio will continue to operate as a standalone organization.

Supporting People with Disabilities

BMS and RayzeBio are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process reasonable workplaceaccommodations/adjustmentsand ongoing support in their roles. Applicants can request a reasonable workplaceaccommodation/adjustmentprior to accepting a job offer. If you require reasonableaccommodations/adjustmentsin completing this application or in any part of the recruitment process direct your inquiries to. Visit access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS and RayzeBio will consider for employment qualified applicants with arrest and conviction records pursuant to applicable laws in your area.

If you live in or expect to work from Los Angeles County if hired for this position please visit this page for important additional information: Protection

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