Research Associate II Senior Research Associate

The Role:

Generate Biomedicines is seeking a Research Associate II/Senior Research Associate to join our CryoEM Group in generating large-scale protein structural datasets. This role offers the opportunity to work at the intersection of protein biochemistry and cutting-edge structural biology contributing to our mission of accelerating drug discovery through advanced imaging technologies.

Heres how you will contribute:

• Perform protein purification complexation vitrification and clipping ensuring high-quality sample preparation for CryoEM.
• Load and operate CryoEM microscopes executing data collection with automated workflows.
• Collaborate with multidisciplinary teams to support high-throughput protein structure determination.
• Follow standard operating procedures (SOPs) and contribute to process optimization.
• Document experimental data and report findings in internal databases.
• Interpret and troubleshoot experimental data contributing to planning and prioritization of concurrent CryoEM experiments.
• Apply and refine data analysis methods; determine reliability of results and communicate findings in presentations or team meetings.
• Contribute to process optimization and implementation of new protocols.

The Ideal Candidate will have:

• MSc in Biochemistry Structural Biology Biophysics Molecular Biology Chemistry or a related field and 0-2 years of experience or a BSc in Biochemistry Structural Biology Biophysics Molecular Biology Chemistry or a related field with 2-4 years of related experience.
• Hands-on experience in basic wet lab techniques including pipetting buffer preparation and protein purification.
• Strong understanding of protein chemistry concepts such as molarity protein concentration and buffer formulation.
• Ability to work in a fast-paced collaborative research environment.
• Strong attention to detail and ability to troubleshoot technical issues.

Preferred Additional Skills

• Familiarity with structural biology techniques and CryoEM sample preparation.
• Prior exposure to CryoEM workflows or microscope operation with SerialEM.

Who Will Love This Job:

• Youre excited to learn fast and build deep expertise in CryoEM and structural biologythis role offers hands-on training with advanced instrumentation real ownership of experiments and the chance to grow your technical skillset alongside experienced scientists.

Additional Information
On-site position at our Andover MA CryoEM lab
Location: Andover MA (On-site 5 days/week)

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About Generate Biomedicines

We are a clinical-stage generative biology company pioneering the AI revolution in drug design and development. We are advancing a new approach to drug creationone grounded in the ability to design proteins with defined biological intent. By integrating machine learning with large-scale experimentation this approach aims to reduce the uncertainty time and cost associated with developing protein-based medicines.

Founded in 2018 we are advancing a growing pipeline of clinical and preclinical programs across multiple disease areas and protein modalities. By unifying computational design and clinical development within a single operating model we translate this approach into clinical-stage programs and are leading a shift from traditional drug discovery toward systematic drug generation.

At Generate:Biomedicines we collaborate across disciplines in new ways to invent and innovate. We bring diverse perspectives to a shared goal of delivering better medicines to patients in need faster guided by our values and leadership behaviors.

Generate:Biomedicines is committed to equal employment opportunity regardless of race color ancestry religion sex national origin sexual orientation age citizenship marital status disability gender identity or Veteran status.

Recruitment & Staffing Agencies: Generate:Biomedicines does not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to Generate:Biomedicines or its employees is strictly prohibited unless contacted directly by the Companys internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of Generate:Biomedicines and the Company will not owe any referral or other fees with respect thereto.