Pharmacology Senior Research Scientist-(Immunology)

General Summary:

Vertex is seekingahighly motivated and passionateSenior Research Scientistto join the In Vivo Integrated Pharmacology team.Thisrolewillleadthe design execution and interpretation of complexin vivoandin vitroimmunological and pharmacological studies toevaluate howcompoundmodulatedisease biology.This individualis expected tobring scientific creativitytechnicalversatility and a high level ofproductivitywhilebalancingmultiple priorities in adynamicenvironment.The idealcandidateisadaptablecollaborativeandcontributesto thedevelopment ofpharmacologicalstrategies that advance programs from late discovery through IND-enabling stages. Thiscalls fora deepexpertise inimmunology and pharmacologyalong with a broad understanding of relatedscientific disciplines and literature.

Key Duties and Responsibilities:

• Design and execute elaborate technically challenging and conceptually connected multi-component immunological and pharmacological experiments.

• Transformcomplex multidimensionalexperimentaldata into clear hypotheses and actionable experimental directions to guide project decisions and new research activities.

• Prioritize and balance studies across multiple projects ensuring alignment with project and corporate objectivesand timelines.

• Perform advanced experimental troubleshooting develop novel methodologies and validate innovative experimental approaches to address critical project goals.

• Drive methodological innovationbyincorporating emerging technologies andintegratingprinciples from otheradjacent scientificdisciplines toaddressresearch methodologies to address significant scientific questionsmaintain a competitiveadvantage.

• Conduct comprehensive reviews of relevant scientific literature both within immunology and pharmacology and across related fields to integrate new insights into research activities.

• Research external intellectual property relevant to projects and areas of pursuit contributing to the strategic direction of the research.

• Prepare and deliver high-quality study presentations effectively communicating experimental conclusions at internal and external meetings.

• Contribute substantively to patent and/orpublication preparation ensuring the dissemination of impactful scientific findings.

• Perform other duties as assigned.

Knowledge and Skills:

• Demonstrated expertise in designing executing and interpreting complex immunological and pharmacological in vivo and in vitro experiments to measure the action of compounds in disease-relevant contexts.

• Proven ability to develop and optimize sophisticated in vivo models of inflammation and autoimmune diseases ensuring robust and reproducible results to advance therapeutic discovery.

• Advanced skills in immunological techniques including flow cytometry immunophenotyping and in vitro/ex vivo cellular assays to characterize immune responses and compound efficacy.

• Proficiency in a wide rangeofinvivo techniques including routes of administration blood/tissue harvesting and processing for cellular/molecular analyses of immune responses and target engagement in immune models.

• Broad and deep knowledge of immunology and pharmacology principles with the ability to apply this knowledge to complex experimental designs.

• Demonstrates a high level of productivity experimental creativity and the ability to disseminate ideas effectively across disciplines.

• Strong problem-solving skills with the ability to address complex challenges and achieve critical project goals.

• Exceptional communication skills including the ability to present technical information effectively to diverse audiences.

Education and Experience:

• Ph.D. in Immunology Pharmacology or a related discipline with 2 years of relevant post-doctoral employment experience or

• Masters degree with 5 years of relevant employment experience or

• Bachelors degree with 8 years of relevant employment experience.