Director, Clinical Genomics Operations & Variant Science – Invitae – Remote
San Francisco, CA - USA
Job Summary
Labcorp is seeking a US remote-based Director of Clinical Genomics Operations & Variant Science to join its Invitae Genetics division!
Responsibilities:
- Provide strategic technical and operational leadership for clinical interpretation and reporting across WGS WES targeted NGS panels and chromosomal microarray (CMA)
- Serve as subject matter expert in genomic testing workflows interpretation frameworks and clinical reporting standards ensuring scientific rigor clinical relevance and regulatory compliance
- Oversee day-to-day operational performance including production scheduling capacity planning process health monitoring and escalation of operational incidents
- Establish optimize and scale end-to-end workflows for clinical interpretation and reporting using continuous improvement methodologies
- Define implement and monitor key operational metrics to assess performance identify risk and communicate trends to senior leadership
- Ensure delivery of high-quality clinical reports meeting established turnaround time accuracy and quality benchmarks
- Lead root-cause analysis and implementation of corrective and preventive actions for complex production issues
- Develop and execute operational strategies aligned with broader organizational OKRs
- Mentor and coach scientists genetic counselors and operational partners fostering a culture of continuous learning and scientific excellence
- Collaborate cross-functionally with Laboratory Bioinformatics Product Quality Regulatory IT and Clinical Development to support launch of new assays tools and initiatives
- Act as an individual-contributor Director with expectation of transitioning to formal people management within 6 months
Minimum Qualifications:
- PhD in Biological Sciences Molecular Genetics or Human Genetics with 5 years or more of related work experience; OR Masters degree in Genetic Counseling Biological Sciences Molecular Genetics or Human Genetics with 6 years or more of related work experience; OR Bachelors degree in Genetics Biological Sciences Molecular Genetics or Human Genetics with 7 years or more of related work experience
- 3 years or moreof demonstrated expertise in variant interpretation curation and clinical reporting for NGS-based assays including WGS and WES and/or targeted panels. This includes current or previous hands-on variant interpretation experience
- 3 years or moreof experience driving operational efficiency and scaling production workflows supporting clinical interpretation and/or reporting
- 3 years or more experienceof demonstrated ability to coach develop and elevate operational or production teams with strong organizational and execution skills
- 3 years or moreof experience managing or influencing complex initiatives with measurable outcomes in a high-throughput setting
- 5 yearsor more of experience in operational leadership including managing a team workflow optimization capacity planning performance metrics and cross-functional execution
Preferred Qualifications:
- 5 yearsor more of Director-level experience within a CLIA-certified diagnostic laboratory or similarly regulated clinical setting
- 3 years or moreof experience developing launching or scaling clinical genomic assays or interpretation programs
- 2 yearsor more of experience with rapid or NICU whole genome sequencing (NICU WGS) and high-acuity clinical workflows
- 2 years or moreof familiarity with copy number variant (CNV) detection and interpretation across CMA and NGS-based platforms
- Lean Six Sigma (Green Belt or higher) certification or equivalent continuous improvement experience
- 3 yearsor more of experience scaling high-throughput clinical interpretation/reporting operations
Additional Job Standards:
- Background or interest in clinical domains such as oncology cardiology neurology carrier screening metabolic disorders pediatrics or cytogenomics
- Operational leadership supporting clinical interpretation or reporting workflows including capacity planning quality management and process optimization
- Cross-functional collaboration with laboratory bioinformatics product quality regulatory or clinical development teams
- Experience supporting the development launch or scaling of clinical genomic assays or interpretation programs
- Demonstrated ability to independently lead complex initiatives and influence outcomes without direct people management responsibility
- Strong understanding of clinical reporting operations quality systems and regulated laboratory environments (e.g. CLIA CAP)
- Proven ability to operate at a Director level balancing strategic planning with hands-on operational leadership
- Strong analytical problem-solving and communication skills with the ability to translate technical and operational data into executive-level insights
- Demonstrated technical expertise with whole genome sequencing (WGS) and whole exome sequencing (WES) including strong understanding of clinical interpretation frameworks reporting standards and end-to-end workflows
- Excellent written verbal and interpersonal communication skills
- Ability to adapt to significant change that is inherent in development and
This is a Director-level role with leadership accountability and strong operational ownership. While initially an individual contributor role it is expected to transition into formal people management within approximately 6 months.
Application Window Closes: 5/1/2026
**Salary Range: $125000 - $225000/ year
All job offers will bebased on a candidates skills and prior relevant experience applicabledegrees/certificationsas well as internal equity and market data.
The position is also eligible for an annual bonus under the Labcorp Bonus are payable based on corporate and/or business segment performance and are subject to individual performance modifiers.
Benefits:Employees regularly scheduled to work 20 or more hours per week are eligible for comprehensive benefits including: Medical Dental Vision Life STD/LTD 401(k) Paid Time Off (PTO) or Flexible Time Off (FTO) Tuition Reimbursement and Employee Stock Purchase regularly scheduled to work less than 20hoursCasual Intern and Temporary employees are only eligible toparticipatein the 401(k) who are regularly scheduled toworka 7 on/7 off schedule are eligible to receive all the foregoing benefits except PTO or FTO. For more detailed information pleaseclick here.
Labcorp is proud to be an Equal Opportunity Employer:
Labcorp strives for inclusion and belonging in the workforce and does not tolerate harassment or discrimination of any kind. We make employment decisions based on the needs of our business and the qualifications and merit of the individual. Qualified applicants will receive consideration for employment without regard to race religion color national origin sex (including pregnancy childbirth or related medical conditions) family or parental status marital civil union or domestic partnership status sexual orientation gender identity gender expression personal appearance age veteran status disability genetic information or any other legally protected characteristic. Additionally all qualified applicants with arrest or conviction records will be considered for employment in accordance with applicable law.
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Required Experience:
Director
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