Senior Principal Scientist, Clinical and Biomarker Data Analytics (Neuroscience)

At Johnson & Johnsonwe believe health is everything. Our strength in healthcare innovation empowers us to build aworld where complex diseases are prevented treated and curedwhere treatments are smarter and less invasive andsolutions are our expertise in Innovative Medicine and MedTech we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow and profoundly impact health for more at

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Johnson & Johnson is recruiting for a Senior Principal Scientist Clinical and Biomarker Data Analytics (Neuroscience) to be based at one of our sites in San Diego CA; Titusville NJ; Spring House PA; or Boston MA.

Our expertise in Innovative Medicine is informed and inspired by patients whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Our Neuroscience team tackles the worlds toughest brain health challenges including multiple sclerosis Alzheimers disease Parkinsons disease myasthenia gravis epilepsy major depressive disorder bipolar disorder schizophrenia and autism. This patient-focused team helps address some of the most complex diseases of our time.

Join us in developing treatments finding cures and pioneering the path from lab to life while championing patients every step of the way.

Learn more at Neuroscience Precision Measures (PM) Team is an integrated scientific organization supporting the delivery of precision therapeutics to patients with CNS disorders across neuropsychiatry neurodegeneration and ophthalmology. The team brings together disease experts biomarker scientists computational biologists and leaders in imaging and digital health and partners closely with Neuroscience Discovery and Development organizations to advance an industryleading portfolio of novel mechanisms.

Precision Measures advances measurement science grounded in human dataincluding fluids tissues highdimensional biology and neuroimagingto support the endtoend close collaboration with internal and external partners the organization delivers decisionenabling insights spanning target selection early and late clinical development regulatory submissions and postmarket evidence generation.

The Senior Principal Scientist Clinical and Biomarker Data Analytics is a senior individual contributor who serves as a scientific and analytical leader supporting neuroscience biomarker discovery screening funnel optimization and biomarker endpoint development from discovery through clinical development. Reporting to the Head of Quantitative Imaging and Clinical Biomarkers the incumbent works in close partnership with Precision Measures and across Neuroscience functions on advanced quantitative and modeling approaches to enable robust biomarker strategies and development decisions.

Operating with minimal direction the incumbent leads biomarkers analyses across disease areas and measurement modalities. The role requires independent scientific judgment and deep quantitative expertise to evaluate and validate biomarkers in their context of use. The incumbent serves as a key scientific authority on crossfunctional teams and contributes to biomarker strategy development analytical evidence packages and expert input.

Key Responsibilities

• Serve as a senior scientific leader for clinical and biomarker data analytics partnering with Precision Measures and Neuroscience functions to drive data-informed biomarker strategy across discovery and development.

• Lead quantitative analyses supporting biomarker discovery screening funnel performance and endpoint development ensuring analytical rigor and fitness-for-purpose in a clinical trial context.

• Apply advanced modeling and statistical methods to integrate multimodal biomarker data (e.g. imaging fluid clinical endpoints) and generate interpretable evidence to inform decision-making.

• Quantify and interpret relationships between biomarkers and clinical outcomes supporting assessment of biomarker utility for enrichment stratification and endpoint development.

• Provide hands-on analytical leadership for biomarker datasets including data curation modeling validation and interpretation with emphasis on reproducibility and scalability.

• Partner closely with Clinical Statistics Data Science and operational teams to ensure analytical approaches are aligned with study objectives protocols and development timelines.

• Operate effectively in cross functional teams influencing strategy and execution while leading complex analytical workstreams with broad autonomy and minimal supervision.

• Provide technical guidance and mentorship to project teams contributing to capability building and scientific excellence across the organization.

• 10% travel

Required Qualifications

• A Ph.D. degree in bioinformatics biomedical engineering applied statistics or related fields.

• At least 10 years of relevant experience.

• A strong publication record including first author publications in peer-reviewed journals.

• Excellent communication collaboration and influencing skills.

• Proven ability to work in teams with diverse expertise and lead projects with broad autonomy.

Preferred Qualifications

• Hands-on experience with biomarker discovery or use of Neuroscience biomarkers in clinical trials.

• Hands-on experience with advanced modeling methods (e.g. statistical modeling multivariate methods machine learning or related quantitative approaches).

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race color religion sex sexual orientation gender identity age national origin disability protected veteran status or other characteristics protected by federal state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants needs. If you are an individual with a disability and would like to request an accommodation please contact us via or contact AskGS to be directed to your accommodation resource.

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