Senior Director, Medical, Translational and Computational Pathologist

GSK is seeking a highly motivated Pathologist preferable with industry experience to provide scientific medical and strategic leadership across translational and computational pathology. This role bridges traditional diagnostic pathology with advanced biomarker science digital pathology and AIenabled image analytics to support tissuebased biomarker discovery precision medicine and diagnostic development from firstinhuman studies through latestage clinical development. The candidate should be based in Philadelphia USA or willing to relocate.

Key Responsibilities

Scientific Medical and Translational Leadership

• Provide timely highquality pathology expertise to GSK leaders scientists and study teams operating within GSK policies and regulatory frameworks.
• Guide and refine clinical development strategies across oncology (primary focus) respiratory immunology and infectious diseases ensuring integration of histopathology translational research and precision medicine.
• Partner with biomarker scientists and translational research teams to enable rigorous biomarker strategies including study selection patient stratification and hypothesisdriven assay deployment.

Biomarker & Assay Development

• Provide strategic and scientific oversight of clinical biomarker assay development and validation both internally and through external laboratories and CROs.
• Lead the development and deployment of innovative clinicalgrade bioassays to support program needs including:
  • Immunohistochemistry (IHC; conventional and multiplex/multicolor)
  • Multiplex immunofluorescence (mIF)
  • In situ hybridization (ISH)
  • Spatial omics (highplex proteomics and/or transcriptomics)
  • Genomics (WGS exome bulk and singlecell RNAseq cfDNA)
  • Flow cytometry from tissue and liquid specimens (e.g. peripheral blood pleural fluid)
• Ensure assay performance analytical rigor data interpretation and regulatory readiness.

Clinical Development & Trial Support

• Provide direct pathology support to clinical development and translational medicine teams across programs.
• Advise on clinical trial design execution and governance optimizing:
  • Diagnostic inclusion/exclusion criteria
  • Tissue collection strategies
  • Pathology endpoints and pathologic response assessments
  • Image and data asset generation
• Review and contribute to study protocols and key clinical documentation.
• Serve as a subject matter expert in interactions with health authorities including preparation of regulatory submissions and responses particularly for companion diagnostics.

Computational & Digital Pathology

• Drive computational pathology (CP) capabilities in collaboration with histotechnology digital pathology and AI/ML teams.
• Lead development of fitforpurpose image analysis workflows and AIenabled models for quantification of highdimensional pathology data (e.g. histopathology images spatial biology).
• Advance internal CP infrastructure including wholeslide imaging QC review metadata management annotation strategies and digital consensus workflows.
• Enable rapid scalable data generation to support early through latephase clinical programs (Ph1Ph3).

External Engagement Strategy & Leadership

• Support clinical trial advisory boards and engage external key opinion leaders to inform pathologyrelated endpoints and strategy.
• Interface with clinical trial sites external laboratories CROs and technology partners.
• Provide pathology input into external technology assessments business development opportunities and alliance management.
• Advise commercial and executive leadership on pathology diagnostics and biomarkerrelated matters.
• Take on additional responsibilities as needed to meet evolving organizational priorities.

Basic Qualifications

• Medical Doctor
• Completion of formal postgraduate clinical training clinical residency or specialty training in Pathology Anatomic Pathology (AP) or AP/CP
• Fellowship or sub-specialty training in one or multiple surgical pathology and/or laboratory medicine disciplines.
• Minimum of 5 years post-training experience in research clinical practice or industry.
• Experience with digital and computational pathology tools (e.g. HALO Visiopharm) and strong interest in advancing CP applications.

Preferred Qualifications & Attributes

In addition to the above the following would be preferred

• Medical Doctor PhD
• Subspecialty expertise in surgical pathology relevant to GSK priorities (e.g. gynecologic GU head and neck dermatopathology soft tissue hematopathology pulmonary renal GI/liver).
• Experience in molecular pathology genomics/NGS flow cytometry and/or immunopathology assay validation and clinical interpretation.
• Proven ability to manage multiple programs work effectively in matrixed teams and communicate clearly to diverse scientific clinical and leadership audiences.
• Demonstrated scholarly activity hypothesis-driven research and/or advanced degrees (MS MPH PhD).
• Experience in digital pathology image analysis AI/ML data science bioinformatics or disease genetics.
• Track record of regulatory engagement and/or companion diagnostics development.
• Experience in laboratory leadership quality systems education inspection or CAP/RCP-related activities.
• Experience supporting clinical trials protocol authorship CRO interactions and multinational matrix environments.

Please visit GSK US Benefits Summary to learn more about the comprehensive benefits program GSK offers US employees.

Why GSK

Uniting science technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade as a successful growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.

People and patients around the world count on the medicines and vaccines we make so were committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients accountable for impact and doing the right thing is the foundation for how together we deliver for patients shareholders and our people.

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GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race color religion sex (including pregnancy gender identity and sexual orientation) parental status national origin age disability genetic information (including family medical history) military service or any basis prohibited under federal state or local law.

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