Scientist, Bioanalytical Assays

Company Summary:

Serif Biomedicines is a privately held early-stage biotechnology company developing a novel approach to gene therapy that can address currently untreatable diseases.

Serif Biomedicines was founded by Flagship Pioneering an innovative enterprise that conceives creates resources and grows first-in-category life sciences companies. Flagship Pioneering has created over 100 groundbreaking companies over the past twenty years all of which are pioneering novel and proprietary biological industrial and engineering approaches to solve major needs in human health and sustainability. These companies include Moderna (MRNA) Syros Pharmaceuticals (SYRS) Seres Therapeutics (NASDAQ:MCRB) Generate Biomedicines Tessera Tx Evelo Biosciences (EVLO) and Indigo Agriculture.

Position Summary:

We are seeking a highly motivated and experienced Scientist with expertise in bioanalytical assays. This full-time bench scientist position requires expertise in bioanalytical platforms LNPs nucleic acid therapies and biodistribution studies. This individual will have the opportunity to directly contribute to the bioanalytical assay development for platform and therapeutic areas and work in a dynamic and fast-paced entrepreneurial environment as part of a highly collaborative team.

Key Responsibilities:

• Design develop optimize and execute bioanalytical assays to support nonclinical studies including PK PD biomarker and immunogenicity endpoints
• Execute ligand-binding assays and cell-based assays ensuring robust assay performance data quality and compliance with applicable guidelines
• Design optimize and execute biodistribution studies (flow cytometry and histological techniques) for LNP/nucleic acid therapies
• Collaborate closely with CMC molecular biology and cell biology teams to screen cargoes (immunogenicity assessment etc.) and ensure timely delivery of high-quality data and summarize results
• Establish and execute various cell-based assays to assess immunogenicity to nucleic acid cargoes and establish release criteria for preclinical payloads
• Design establish and execute assays for assessing various in vivo immunogenicity predictors for LNP/nucleic acid therapies including but not limited to biomarkers cytokines complement activation and anti-drug antibodies (ADA)
• Execute test procedures such as sample extraction and measurement by flow cytometry ELISA MSD Luminex bDNA ddPCR RNAscope and perform data interpretation
• Analyze and summarize scientific data and maintain timely documentation and completion of electronic lab notebooks in compliance with industry guidelines

• Present at project team meetings and to relevant stakeholders

Qualifications:

• Ph.D. in biochemistry pharmaceutical sciences cell biology or related field with 2 plus years of industry experience
• Proficiency in ddPCR ligand binding assays and histological techniques
• Experience developing bioanalytical methods to measure drugs and biomarkers for LNP delivery of nucleic acid cargoes
• Strong communication presentation and interpersonal skills
• Experience with non-viral delivery technologies and nucleic acid modalities is preferred
• Attention to detail strategic thinking problem solving and decision-making skills

We are an equal opportunity employer. All qualified applicants will be considered for employment without regard to race color religion sex sexual orientation gender identity national origin disability protected veteran status or any other characteristic protected by law.

We recognize that great candidates often bring unique strengthswithout fulfilling every qualification. If you have some of the experience listed above but not all please apply anyway. We are dedicated to building diverse and inclusive teams and look forward to learning more about your backgroundand interest in Flagship.

Recruitment & Staffing Agencies: Flagship Pioneering and its affiliated Flagship Lab companies (collectively FSP) do not accept unsolicited resumes from any source other than candidates. The submission of unsolicited resumes by recruitment or staffing agencies to FSP or its employees is strictly prohibited unless contacted directly by Flagship Pioneerings internal Talent Acquisition team. Any resume submitted by an agency in the absence of a signed agreement will automatically become the property of FSP and FSP will not owe any referral or other fees with respect thereto.

The salary range for this role is $100000 - $143000. Compensation for the role will depend on a number of factors including a candidates qualifications skills competencies and experience. FL87 currently offers healthcare coverage annual incentive program retirement benefits and a broad range of other benefits. Compensation and benefits information is based on FL87s good faith estimate as of the date of publication and may be modified in the future.

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